Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-yefM/Txe-RelB |
| Location | 1898594..1899123 | Replicon | chromosome |
| Accession | NZ_AP019757 | ||
| Organism | Coxiella burnetii strain 406 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | Q83AB3 |
| Locus tag | QMM28_RS10575 | Protein ID | WP_005769718.1 |
| Coordinates | 1898848..1899123 (+) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | Q83AB4 |
| Locus tag | QMM28_RS10570 | Protein ID | WP_005769716.1 |
| Coordinates | 1898594..1898848 (+) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMM28_RS10525 (CBU406_C19070) | 1893638..1894012 | + | 375 | WP_005769706.1 | hypothetical protein | - |
| QMM28_RS10530 (CBU406_C19080) | 1894057..1894755 | + | 699 | WP_010958581.1 | outer membrane beta-barrel protein | - |
| QMM28_RS10535 (CBU406_C19090) | 1894819..1895760 | + | 942 | WP_005769709.1 | S49 family peptidase | - |
| QMM28_RS10540 (CBU406_C19100) | 1895773..1896648 | + | 876 | WP_010958582.1 | symmetrical bis(5'-nucleosyl)-tetraphosphatase | - |
| QMM28_RS10545 | 1896624..1896728 | + | 105 | WP_230578142.1 | type II toxin-antitoxin system YoeB family toxin | - |
| QMM28_RS10550 (CBU406_C19110) | 1896797..1896931 | + | 135 | WP_010958583.1 | hypothetical protein | - |
| QMM28_RS10555 (CBU406_C19120) | 1897115..1898134 | + | 1020 | WP_040953503.1 | IS110-like element IS1111A family transposase | - |
| QMM28_RS10560 (CBU406_C19130) | 1898131..1898403 | - | 273 | WP_099140165.1 | hypothetical protein | - |
| QMM28_RS10565 | 1898369..1898485 | - | 117 | Protein_2062 | hypothetical protein | - |
| QMM28_RS10570 (CBU406_C19140) | 1898594..1898848 | + | 255 | WP_005769716.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| QMM28_RS10575 (CBU406_C19150) | 1898848..1899123 | + | 276 | WP_005769718.1 | Txe/YoeB family addiction module toxin | Toxin |
| QMM28_RS10580 (CBU406_C19160) | 1899096..1899581 | - | 486 | WP_005769725.1 | dihydrofolate reductase | - |
| QMM28_RS10585 (CBU406_C19170) | 1899578..1900381 | - | 804 | WP_017253341.1 | epoxyqueuosine reductase QueH | - |
| QMM28_RS10590 (CBU406_C19180) | 1900577..1900864 | + | 288 | WP_005769730.1 | acylphosphatase | - |
| QMM28_RS10595 (CBU406_C19190) | 1900840..1901394 | - | 555 | WP_005769732.1 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | - |
| QMM28_RS10600 (CBU406_C19200) | 1901407..1902351 | - | 945 | WP_010958586.1 | methionyl-tRNA formyltransferase | - |
| QMM28_RS10605 (CBU406_C19210) | 1902539..1903465 | + | 927 | WP_040948034.1 | DNA-processing protein DprA | - |
| QMM28_RS10610 (CBU406_C19220) | 1903462..1903941 | + | 480 | WP_010958588.1 | DUF494 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1897115..1898134 | 1019 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 11150.86 Da Isoelectric Point: 9.6762
>T33003 WP_005769718.1 NZ_AP019757:1898848-1899123 [Coxiella burnetii]
MQISFTPEAWEDYLYWQKFDKKMLRRINELIKDAMHEPFSGKGKPEPLKFELQGYWSRRLDQEHRLVYKVLDDSLMIIAA
RFHYNRLNSKN
MQISFTPEAWEDYLYWQKFDKKMLRRINELIKDAMHEPFSGKGKPEPLKFELQGYWSRRLDQEHRLVYKVLDDSLMIIAA
RFHYNRLNSKN
Download Length: 276 bp
>T33003 NZ_AP019757:1898848-1899123 [Coxiella burnetii]
ATGCAAATTTCCTTCACGCCCGAAGCCTGGGAAGATTATTTATATTGGCAAAAATTCGACAAAAAAATGCTTCGACGCAT
TAATGAACTCATTAAGGATGCTATGCACGAGCCTTTTTCCGGAAAGGGAAAGCCAGAACCTTTAAAATTTGAATTACAAG
GATATTGGTCAAGACGATTAGATCAAGAACATCGATTGGTCTACAAAGTTTTAGACGATTCGTTAATGATTATCGCCGCA
AGATTTCACTATAATCGCCTTAATTCTAAAAACTGA
ATGCAAATTTCCTTCACGCCCGAAGCCTGGGAAGATTATTTATATTGGCAAAAATTCGACAAAAAAATGCTTCGACGCAT
TAATGAACTCATTAAGGATGCTATGCACGAGCCTTTTTCCGGAAAGGGAAAGCCAGAACCTTTAAAATTTGAATTACAAG
GATATTGGTCAAGACGATTAGATCAAGAACATCGATTGGTCTACAAAGTTTTAGACGATTCGTTAATGATTATCGCCGCA
AGATTTCACTATAATCGCCTTAATTCTAAAAACTGA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9624.25 Da Isoelectric Point: 10.4802
>AT33003 WP_005769716.1 NZ_AP019757:1898594-1898848 [Coxiella burnetii]
MNVVTFSELRAQLKKILDLSADQHEPVVVKRPNKETMVILSLRDFEALKETAYLLSNEANAARLRQSIRSLKQGKAQKKK
LMED
MNVVTFSELRAQLKKILDLSADQHEPVVVKRPNKETMVILSLRDFEALKETAYLLSNEANAARLRQSIRSLKQGKAQKKK
LMED
Download Length: 255 bp
>AT33003 NZ_AP019757:1898594-1898848 [Coxiella burnetii]
ATGAACGTAGTTACTTTTAGCGAACTCAGGGCGCAACTTAAAAAAATCTTGGATCTTTCCGCCGATCAACACGAACCTGT
CGTCGTTAAACGGCCAAATAAAGAAACCATGGTCATTTTATCTTTACGCGACTTTGAGGCTCTAAAAGAAACAGCTTATC
TCTTAAGTAACGAAGCTAATGCGGCCCGTCTTCGTCAGTCTATCCGCAGCTTAAAACAAGGCAAGGCACAAAAAAAGAAA
TTAATGGAAGATTAA
ATGAACGTAGTTACTTTTAGCGAACTCAGGGCGCAACTTAAAAAAATCTTGGATCTTTCCGCCGATCAACACGAACCTGT
CGTCGTTAAACGGCCAAATAAAGAAACCATGGTCATTTTATCTTTACGCGACTTTGAGGCTCTAAAAGAAACAGCTTATC
TCTTAAGTAACGAAGCTAATGCGGCCCGTCTTCGTCAGTCTATCCGCAGCTTAAAACAAGGCAAGGCACAAAAAAAGAAA
TTAATGGAAGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|