Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2080325..2080889 Replicon chromosome
Accession NZ_AP019755
Organism Nitrosomonas stercoris strain KYUHI-S

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag Nstercoris_RS09970 Protein ID WP_172631638.1
Coordinates 2080325..2080666 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag Nstercoris_RS09975 Protein ID WP_172631321.1
Coordinates 2080659..2080889 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Nstercoris_RS09945 2076008..2076009 - 2 WP_172629911.1 IS5 family transposase -
Nstercoris_RS09950 2076472..2076933 + 462 WP_172631317.1 hypothetical protein -
Nstercoris_RS09955 2076937..2077998 - 1062 WP_172631318.1 DNA polymerase III subunit delta' -
Nstercoris_RS09960 2078086..2079543 + 1458 WP_172631319.1 Na+/H+ antiporter NhaC -
Nstercoris_RS09965 2079547..2080191 - 645 WP_172631320.1 dTMP kinase -
Nstercoris_RS09970 2080325..2080666 - 342 WP_172631638.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
Nstercoris_RS09975 2080659..2080889 - 231 WP_172631321.1 CopG family transcriptional regulator Antitoxin
Nstercoris_RS09980 2081275..2081556 - 282 WP_197734577.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
Nstercoris_RS09985 2081816..2082145 + 330 WP_172631323.1 type II toxin-antitoxin system RelE/ParE family toxin -
Nstercoris_RS09990 2082142..2082423 + 282 WP_172631324.1 helix-turn-helix domain-containing protein -
Nstercoris_RS09995 2082896..2083333 - 438 WP_172631325.1 pilin -
Nstercoris_RS11450 2083497..2083646 - 150 WP_206751886.1 hypothetical protein -
Nstercoris_RS10000 2083655..2084639 - 985 Protein_1958 Rpn family recombination-promoting nuclease/putative transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2079547..2091487 11940


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13148.48 Da        Isoelectric Point: 10.5218

>T33001 WP_172631638.1 NZ_AP019755:c2080666-2080325 [Nitrosomonas stercoris]
VIDFKQLDIYWVDLEPTKGAETRKLRPCVIIQSDLVNTQSRTLIVAPLLPQHKPWPFAVNLKPSEKNGLDKNRHVNLKQL
RAVDITRIRKKQGQLEKQYKNPIKEALIIIFDL

Download         Length: 342 bp

>T33001 NZ_AP019755:c2080666-2080325 [Nitrosomonas stercoris]
GTGATTGATTTCAAACAACTGGATATTTATTGGGTAGATCTTGAGCCAACGAAGGGAGCAGAAACAAGAAAACTAAGGCC
GTGTGTCATTATTCAAAGCGATCTGGTTAACACCCAATCCAGAACCCTGATTGTTGCTCCCTTGCTCCCCCAGCATAAAC
CTTGGCCATTTGCTGTGAATCTAAAACCCTCTGAAAAAAATGGTTTGGATAAGAATCGTCATGTCAATCTTAAGCAATTA
CGCGCGGTTGATATTACACGTATCAGGAAAAAACAAGGTCAACTTGAAAAACAATATAAAAATCCTATCAAGGAAGCTCT
AATAATCATTTTTGACTTGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8606.46 Da        Isoelectric Point: 3.9285

>AT33001 WP_172631321.1 NZ_AP019755:c2080889-2080659 [Nitrosomonas stercoris]
MSYRITITLDEETFVFLNDVASGNRSAYVNQLLKQERRNFLQAALCKANQEEAEDADYLTELQAWESTLADGLASD

Download         Length: 231 bp

>AT33001 NZ_AP019755:c2080889-2080659 [Nitrosomonas stercoris]
ATGTCTTACAGAATAACTATTACACTTGACGAAGAGACTTTTGTTTTTCTGAATGATGTTGCCAGCGGTAATCGTAGTGC
CTACGTTAATCAGCTGTTAAAACAGGAGCGCAGAAATTTCTTGCAGGCAGCATTATGTAAAGCAAATCAGGAAGAGGCAG
AAGATGCAGACTACCTAACAGAATTACAAGCATGGGAGAGTACGCTGGCAGATGGGTTGGCTAGTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References