Detailed information of TA system TA033000

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 690856..691333
• Replicon: chromosome
• Accession: NZ_AP019755
• Organism: Nitrosomonas stercoris strain KYUHI-S

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: Nstercoris_RS03375
• Protein ID: WP_172630236.1
• Coordinates: 690856..691122 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: Nstercoris_RS03380
• Protein ID: WP_172630237.1
• Coordinates: 691106..691333 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Nstercoris_RS03360	688551..689885	+	1335	WP_197734592.1	alpha-amylase	-
Nstercoris_RS03365	690282..690374	-	93	WP_172631542.1	integrase core domain-containing protein	-
Nstercoris_RS03370	690386..690745	+	360	WP_172630235.1	hypothetical protein	-
Nstercoris_RS03375	690856..691122	-	267	WP_172630236.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
Nstercoris_RS03380	691106..691333	-	228	WP_172630237.1	ribbon-helix-helix protein, CopG family	Antitoxin
Nstercoris_RS03385	691577..691795	-	219	WP_172630238.1	HigA family addiction module antidote protein	-
Nstercoris_RS03390	691806..692095	-	290	Protein_667	type II toxin-antitoxin system RelE/ParE family toxin	-
Nstercoris_RS03395	692287..695373	-	3087	WP_172630239.1	efflux RND transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10322.96 Da
• Isoelectric Point: 9.0915

>T33000 WP_172630236.1 NZ_AP019755:c691122-690856 [Nitrosomonas stercoris]
MVWMIDYADSAVSQLCKLDRQTAKRIINFMEERVSMVDDPRSTGKALTGPFNSFWRYRVGDYRIVCDIQDGVLHVLVLRV
GHRKEVYR

Nucleotide

• Length: 267 bp

>T33000 NZ_AP019755:c691122-690856 [Nitrosomonas stercoris]
TTGGTTTGGATGATTGACTATGCCGATTCGGCTGTGTCACAGTTGTGTAAGCTAGATCGGCAAACCGCAAAGCGGATCAT
CAACTTCATGGAAGAACGGGTTTCGATGGTTGATGATCCACGTAGTACCGGCAAGGCTCTTACTGGTCCATTCAATAGCT
TTTGGCGCTACCGCGTAGGCGATTATCGGATCGTCTGTGATATTCAAGATGGTGTACTACATGTTCTTGTACTACGGGTA
GGCCATCGCAAAGAGGTATACCGATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8567.63 Da
• Isoelectric Point: 5.1425

>AT33000 WP_172630237.1 NZ_AP019755:c691333-691106 [Nitrosomonas stercoris]
MATSIRLAPEIEKRLDSLAAETGRTKAYYLRQIIEQGIEEVEDYYLAANTQERIRKGLEKTHSADTVRKNLGLDD

Nucleotide

• Length: 228 bp

>AT33000 NZ_AP019755:c691333-691106 [Nitrosomonas stercoris]
ATGGCAACATCTATTCGACTGGCACCGGAAATTGAAAAAAGGCTGGATTCGCTTGCAGCCGAAACCGGGCGAACAAAGGC
TTATTATCTGCGTCAAATTATTGAGCAAGGCATTGAAGAAGTGGAGGACTACTACCTTGCCGCCAACACGCAAGAGCGAA
TTCGTAAGGGGCTAGAAAAAACACACTCGGCTGATACCGTAAGGAAAAACCTTGGTTTGGATGATTGA