Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2288966..2290314 Replicon chromosome
Accession NZ_AP019753
Organism Pantoea ananatis strain FU-01

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PAFU01_RS10735 Protein ID WP_265166098.1
Coordinates 2289205..2290314 (+) Length 370 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PAFU01_RS10730 Protein ID WP_014605801.1
Coordinates 2288966..2289205 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAFU01_RS10715 (PAFU01_20900) 2284558..2285946 + 1389 WP_014605798.1 MFS transporter -
PAFU01_RS10720 (PAFU01_20910) 2285969..2288344 + 2376 WP_014605799.1 glycoside hydrolase family 3 N-terminal domain-containing protein -
PAFU01_RS10725 (PAFU01_20920) 2288408..2288851 - 444 WP_014605800.1 GNAT family N-acetyltransferase -
PAFU01_RS10730 (PAFU01_20930) 2288966..2289205 + 240 WP_014605801.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PAFU01_RS10735 (PAFU01_20940) 2289205..2290314 + 1110 WP_265166098.1 HipA N-terminal domain-containing protein Toxin
PAFU01_RS10740 (PAFU01_20950) 2290360..2290776 - 417 WP_014605803.1 GFA family protein -
PAFU01_RS10745 (PAFU01_20960) 2291227..2293095 - 1869 WP_264417876.1 low affinity potassium transporter Kup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-55)


Sequences

Toxin        


Download         Length: 370 a.a.        Molecular weight: 40901.29 Da        Isoelectric Point: 7.4556

>T32997 WP_265166098.1 NZ_AP019753:2289205-2290314 [Pantoea ananatis]
MAKLIAWINGERTGTLTLHHNGALHFQYDANWLQHPLARPLSLSLPLQRAAMHSEKVMHFFENLLFPSTLIEKDFYPAHP
IKSCEVFAALQKVGHTLPGALSLLPAKRQPVAPDQVTHSVFSPADEAQQFDIDNAYLCLSLARELTIPVPDAVLVHENGI
RKLRTERYDRRWRHDGQHLYHLPEEDVCQALGVPLSGRDEQQGGPGIDDIMALLMGSSSAMKDREDLMRCLVFQWLTGIT
RVNAKHLSLLIARGGSFRLAPFKHLLSACPGLSLRTTDRRDFQLGIGLTGPEGKQHHIDAIGPAHFLALAGSVGFSQAAM
RQILAAFIPGLPAAIIKVRDSLPDDYPLTLADAVFSHAMMMLERVRQAI

Download         Length: 1110 bp

>T32997 NZ_AP019753:2289205-2290314 [Pantoea ananatis]
ATGGCAAAGCTCATTGCCTGGATAAACGGCGAGCGTACGGGAACGCTGACGCTGCATCACAACGGCGCGCTGCATTTCCA
GTATGACGCCAACTGGCTTCAGCATCCGCTTGCCAGACCTCTCTCGCTTTCGTTGCCCTTACAGCGCGCCGCGATGCATT
CTGAGAAAGTCATGCACTTTTTCGAAAACCTTCTCTTTCCCAGCACGTTGATCGAAAAGGATTTTTACCCGGCTCACCCG
ATAAAATCCTGTGAGGTGTTTGCTGCATTGCAGAAAGTGGGACACACATTGCCCGGGGCGCTCAGTCTGCTGCCGGCAAA
GCGGCAGCCCGTCGCGCCGGACCAGGTAACGCACAGCGTCTTCAGCCCCGCCGATGAGGCACAGCAGTTCGATATCGATA
ATGCGTATCTGTGTCTGTCCCTGGCCCGGGAGCTGACTATCCCGGTGCCGGATGCCGTGTTAGTTCATGAGAACGGCATC
CGTAAATTGAGAACAGAACGATACGATCGCCGTTGGCGTCACGACGGACAACACCTTTATCATCTTCCCGAAGAAGACGT
GTGTCAGGCGCTCGGCGTGCCGCTCTCTGGCCGCGATGAGCAGCAGGGCGGTCCGGGAATTGATGACATCATGGCCTTGC
TGATGGGCTCAAGCTCCGCCATGAAAGACCGTGAGGATCTGATGCGCTGTCTGGTATTTCAGTGGCTGACGGGCATCACG
CGCGTCAACGCTAAACATCTTTCGCTGCTGATTGCTCGCGGTGGCAGCTTCCGGCTCGCGCCTTTTAAGCATCTTCTTTC
CGCCTGCCCGGGCCTTTCTCTGCGCACAACAGACAGACGGGATTTCCAGCTGGGGATAGGCCTGACAGGCCCTGAGGGCA
AACAGCATCACATTGACGCGATTGGGCCCGCGCATTTTCTTGCCCTTGCGGGGAGCGTGGGGTTCAGTCAGGCAGCGATG
CGGCAGATACTGGCGGCCTTTATTCCGGGCTTGCCTGCCGCGATTATTAAGGTGCGGGACAGCCTGCCCGATGATTATCC
CCTGACGCTCGCCGATGCGGTTTTCAGCCACGCAATGATGATGCTGGAAAGGGTGCGCCAGGCGATCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8773.03 Da        Isoelectric Point: 7.2012

>AT32997 WP_014605801.1 NZ_AP019753:2288966-2289205 [Pantoea ananatis]
MIYSPRQLANQVRLLRQQNGWTQVELAKKVGLKQATLSHFENAPDTTSLATLFKILQALDLALLLHENSASSAPAEDAW

Download         Length: 240 bp

>AT32997 NZ_AP019753:2288966-2289205 [Pantoea ananatis]
ATGATTTACAGTCCCCGCCAGTTGGCAAATCAGGTCAGGCTACTGCGGCAGCAAAACGGCTGGACCCAGGTCGAACTGGC
GAAAAAAGTGGGCCTGAAACAGGCAACCCTGTCTCACTTCGAAAATGCCCCGGATACAACCTCACTGGCAACGTTGTTCA
AAATCTTACAGGCGCTCGATCTTGCTCTGTTGCTTCATGAAAACAGCGCATCCTCAGCCCCGGCTGAGGATGCCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References