Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1883200..1883790 Replicon chromosome
Accession NZ_AP019753
Organism Pantoea ananatis strain FU-01

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag PAFU01_RS08790 Protein ID WP_029570198.1
Coordinates 1883458..1883790 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag PAFU01_RS08785 Protein ID WP_014605554.1
Coordinates 1883200..1883457 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAFU01_RS08760 (PAFU01_17120) 1878484..1878921 + 438 WP_116197237.1 pentapeptide repeat-containing protein -
PAFU01_RS08765 (PAFU01_17130) 1879197..1880435 - 1239 WP_014605550.1 MFS transporter -
PAFU01_RS08770 (PAFU01_17140) 1881183..1882145 + 963 WP_041930826.1 ferrochelatase -
PAFU01_RS08775 1882398..1882649 + 252 Protein_1704 hypothetical protein -
PAFU01_RS08780 (PAFU01_17150) 1882646..1882852 + 207 WP_029570199.1 cell morphology transcriptional regulator XreR2 -
PAFU01_RS08785 (PAFU01_17160) 1883200..1883457 + 258 WP_014605554.1 antitoxin Antitoxin
PAFU01_RS08790 (PAFU01_17170) 1883458..1883790 + 333 WP_029570198.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PAFU01_RS08800 (PAFU01_17180) 1884051..1884818 - 768 WP_246871492.1 DgsA anti-repressor MtfA -
PAFU01_RS08805 (PAFU01_17190) 1884990..1885667 - 678 WP_013026204.1 hypothetical protein -
PAFU01_RS08810 (PAFU01_17200) 1886279..1886983 + 705 WP_022623305.1 phosphohydrolase -
PAFU01_RS08815 (PAFU01_17210) 1887057..1887311 + 255 WP_013026202.1 Arc family DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-83)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11930.65 Da        Isoelectric Point: 8.0219

>T32987 WP_029570198.1 NZ_AP019753:1883458-1883790 [Pantoea ananatis]
MDRGEIWLVSLDPNAGHEQSGRRPVLIVSPASFNQFTRLPVVVPVTNGGNFARAAGFTVSLNGAGTKTTGVIRCDQPRTL
DMEARNGKYLERIPEVIVNEVVARLEAILS

Download         Length: 333 bp

>T32987 NZ_AP019753:1883458-1883790 [Pantoea ananatis]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTAGATCCGAATGCCGGGCATGAACAAAGCGGAAGGCGTCCAGTACTGAT
TGTTTCTCCGGCGTCTTTTAATCAGTTTACGCGGCTACCTGTGGTTGTTCCCGTGACCAACGGCGGAAACTTTGCCCGCG
CAGCGGGGTTTACTGTTTCACTGAATGGCGCAGGAACGAAAACAACGGGGGTAATTCGTTGTGACCAGCCCAGAACCCTT
GATATGGAAGCCCGGAACGGCAAATATCTTGAACGGATACCTGAAGTTATTGTGAATGAAGTGGTGGCCAGATTAGAGGC
CATTCTGAGCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9253.73 Da        Isoelectric Point: 4.5821

>AT32987 WP_014605554.1 NZ_AP019753:1883200-1883457 [Pantoea ananatis]
MYTTRLKKVGGSVMLAVPPAVLKTLGLSTDSEVGMTIDSGCLIIEPQKRPRYSLEELLAQCDPHAEISEEGREWIDAPAV
GKELL

Download         Length: 258 bp

>AT32987 NZ_AP019753:1883200-1883457 [Pantoea ananatis]
ATGTATACCACTCGTCTGAAAAAGGTTGGCGGATCTGTCATGCTGGCGGTCCCTCCCGCCGTGCTGAAAACGCTGGGGCT
GTCGACGGACAGCGAAGTGGGCATGACCATTGATAGTGGCTGCCTCATAATTGAACCTCAAAAACGTCCCCGCTATTCAC
TCGAAGAACTACTGGCGCAGTGCGATCCGCACGCTGAAATTAGCGAAGAGGGTCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGCTCCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References