Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 928565..929042 Replicon chromosome
Accession NZ_AP019751
Organism Staphylococcus aureus strain JRA307

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FPG46_RS04680 Protein ID WP_000052076.1
Coordinates 928565..928753 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FPG46_RS04685 Protein ID WP_001059690.1
Coordinates 928782..929042 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPG46_RS04650 924555..925076 + 522 WP_000824464.1 hypothetical protein -
FPG46_RS04655 925417..926103 + 687 WP_001793574.1 thermonuclease family protein -
FPG46_RS04660 926460..926660 + 201 WP_001059082.1 cold-shock protein -
FPG46_RS04665 927156..927374 - 219 WP_000005886.1 hypothetical protein -
FPG46_RS04670 927436..927720 - 285 WP_001004401.1 hypothetical protein -
FPG46_RS04675 927808..928377 - 570 WP_001106654.1 hypothetical protein -
FPG46_RS04680 928565..928753 - 189 WP_000052076.1 hypothetical protein Toxin
FPG46_RS04685 928782..929042 - 261 WP_001059690.1 hypothetical protein Antitoxin
FPG46_RS04690 929382..929585 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FPG46_RS04695 929582..929818 - 237 WP_000368687.1 hypothetical protein -
FPG46_RS04700 930042..930623 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
FPG46_RS04705 930696..931313 - 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
FPG46_RS04710 931468..931962 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
FPG46_RS04715 932361..932783 - 423 WP_000974464.1 organic hydroperoxide resistance protein -
FPG46_RS04720 932931..933647 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(43-302)

Antitoxin

Protein of unknown function DUF6088

(7-128)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T32972 WP_000052076.1 NZ_AP019751:c928753-928565 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T32972 NZ_AP019751:c928753-928565 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT32972 WP_001059690.1 NZ_AP019751:c929042-928782 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT32972 NZ_AP019751:c929042-928782 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References