Detailed information of TA system TA032965

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 2649972..2650608
• Replicon: chromosome
• Accession: NZ_AP019740
• Organism: Acinetobacter radioresistens DSM 6976 = NBRC 102413 = CIP 103788 strain NBRC 102413

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: ACRAD_RS12445
• Protein ID: WP_005024450.1
• Coordinates: 2649972..2650358 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A062C3S7
• Locus tag: ACRAD_RS12450
• Protein ID: WP_005018377.1
• Coordinates: 2650351..2650608 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACRAD_RS12430	2645270..2647549	-	2280	WP_005024457.1	TRAP transporter large permease subunit	-
ACRAD_RS12435	2647708..2648301	-	594	WP_005024454.1	rhombosortase	-
ACRAD_RS12440	2648379..2649494	-	1116	WP_005024452.1	hypothetical protein	-
ACRAD_RS12445	2649972..2650358	-	387	WP_005024450.1	hypothetical protein	Toxin
ACRAD_RS12450	2650351..2650608	-	258	WP_005018377.1	succinate dehydrogenase assembly factor 2	Antitoxin
ACRAD_RS12455	2650792..2651964	+	1173	WP_005024448.1	acyl-CoA dehydrogenase family protein	-
ACRAD_RS12460	2652018..2653508	-	1491	WP_005024447.1	NAD(P)/FAD-dependent oxidoreductase	-
ACRAD_RS12465	2653689..2654066	-	378	WP_005018373.1	50S ribosomal protein L17	-
ACRAD_RS12470	2654085..2655092	-	1008	WP_005024445.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 15190.64 Da
• Isoelectric Point: 10.2575

>T32965 WP_005024450.1 NZ_AP019740:c2650358-2649972 [Acinetobacter radioresistens DSM 6976 = NBRC 102413 = CIP 103788]
MVKQCFKLKPSRMAIMVQLSLLLGLLILFYSLLPLGLWLLCSVIGLISYSLFLKAPRPVRFEYLDAEEWTLQFCKAKHLD
RVVIRKIIDHQLYIVIYFQKNQVKPLVIWSDQLSLVYWKKLKMLAKLY

Nucleotide

• Length: 387 bp

>T32965 NZ_AP019740:c2650358-2649972 [Acinetobacter radioresistens DSM 6976 = NBRC 102413 = CIP 103788]
ATGGTTAAGCAGTGTTTTAAGCTGAAACCTAGCCGCATGGCTATTATGGTTCAGCTTTCTTTACTACTCGGTTTGCTGAT
TTTGTTCTATTCACTACTACCGTTGGGGCTATGGCTACTCTGTTCTGTCATTGGTTTGATAAGTTATAGCTTATTTTTAA
AAGCGCCGCGTCCTGTACGCTTTGAATATCTAGATGCTGAAGAATGGACTCTTCAGTTCTGTAAAGCTAAACACTTAGAT
CGTGTTGTGATTCGAAAGATAATTGATCATCAACTTTATATTGTAATTTATTTTCAGAAAAATCAGGTTAAACCCTTGGT
TATCTGGAGTGATCAATTGTCTCTTGTATACTGGAAAAAATTAAAAATGTTAGCCAAGCTGTATTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10209.70 Da
• Isoelectric Point: 4.5925

>AT32965 WP_005018377.1 NZ_AP019740:c2650608-2650351 [Acinetobacter radioresistens DSM 6976 = NBRC 102413 = CIP 103788]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKQYYLQADAEEKATFAELVAQEDPDLLDWFMEVSEPPRPEMKQLIIKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT32965 NZ_AP019740:c2650608-2650351 [Acinetobacter radioresistens DSM 6976 = NBRC 102413 = CIP 103788]
ATGTCTGAAGAAATGACTTTGGAAGAACGTAAAGTAATTTACCGTGCACGCCGGGGACTAAAAGAAATTGATGTATATTT
TGACCCTTATGTAAAACAATATTATTTACAAGCTGATGCGGAAGAAAAAGCCACCTTCGCCGAGCTCGTCGCACAGGAAG
ATCCTGATCTTCTAGACTGGTTTATGGAGGTTTCTGAACCTCCACGTCCGGAGATGAAACAGCTAATCATTAAACTTAAA
CATTATGTCCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A062C3S7