32963

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 4362608..4363250 Replicon chromosome
Accession NZ_AP019731
Organism Bacillus anthracis strain PCr

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag FNQ92_RS23220 Protein ID WP_000635963.1
Coordinates 4362900..4363250 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag FNQ92_RS23215 Protein ID WP_000004570.1
Coordinates 4362608..4362895 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNQ92_RS23190 4357924..4358886 + 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -
FNQ92_RS23195 4358879..4359451 - 573 WP_000906915.1 rhomboid family intramembrane serine protease -
FNQ92_RS23200 4359544..4359903 + 360 WP_000635040.1 holo-ACP synthase -
FNQ92_RS23205 4360060..4361010 + 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
FNQ92_RS23210 4361129..4362298 + 1170 WP_000390596.1 alanine racemase -
FNQ92_RS23215 4362608..4362895 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
FNQ92_RS23220 4362900..4363250 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
FNQ92_RS23225 4363318..4365486 + 2169 WP_000426225.1 RNA-binding transcriptional accessory protein -
FNQ92_RS23230 4365544..4365660 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
FNQ92_RS23235 4365856..4366314 + 459 WP_000344248.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T32963 WP_000635963.1 NZ_AP019731:4362900-4363250 [Bacillus anthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T32963 NZ_AP019731:4362900-4363250 [Bacillus anthracis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT32963 WP_000004570.1 NZ_AP019731:4362608-4362895 [Bacillus anthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT32963 NZ_AP019731:4362608-4362895 [Bacillus anthracis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References