Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 1213158..1214133 Replicon chromosome
Accession NZ_AP019731
Organism Bacillus anthracis strain PCr

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag FNQ92_RS06405 Protein ID WP_002036394.1
Coordinates 1213158..1213895 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag FNQ92_RS06410 Protein ID WP_000588712.1
Coordinates 1214008..1214133 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNQ92_RS06385 1208886..1209668 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
FNQ92_RS06390 1209790..1211475 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
FNQ92_RS06395 1211582..1212064 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
FNQ92_RS06400 1212232..1212969 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
FNQ92_RS06405 1213158..1213895 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
FNQ92_RS06410 1214008..1214133 + 126 WP_000588712.1 hypothetical protein Antitoxin
FNQ92_RS29105 1214210..1214386 + 177 WP_000852614.1 hypothetical protein -
FNQ92_RS06415 1214423..1214704 - 282 WP_001041555.1 hypothetical protein -
FNQ92_RS06420 1214981..1215217 - 237 WP_001021688.1 hypothetical protein -
FNQ92_RS29110 1215556..1215732 + 177 WP_000808045.1 hypothetical protein -
FNQ92_RS06425 1215876..1217345 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
FNQ92_RS06430 1217909..1218379 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T32962 WP_002036394.1 NZ_AP019731:1213158-1213895 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T32962 NZ_AP019731:1213158-1213895 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT32962 WP_000588712.1 NZ_AP019731:1214008-1214133 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT32962 NZ_AP019731:1214008-1214133 [Bacillus anthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References