Detailed information of TA system TA032961

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 986414..986984
• Replicon: chromosome
• Accession: NZ_AP019730
• Organism: Helicobacter pylori strain TN2wt

Toxin (Protein)

• Gene name: relE
• Uniprot ID: M4ZNL7
• Locus tag: DO80_RS04955
• Protein ID: WP_015429138.1
• Coordinates: 986414..986686 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DO80_RS04960
• Protein ID: WP_108304246.1
• Coordinates: 986673..986984 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DO80_RS04935	983063..983830	-	768	WP_108304249.1	ABC transporter ATP-binding protein	-
DO80_RS04940	983830..984810	-	981	WP_108304248.1	iron ABC transporter permease	-
DO80_RS04945	984803..985645	-	843	WP_108304247.1	SDR family oxidoreductase	-
DO80_RS04950	985785..986309	+	525	WP_001135602.1	acyl-CoA thioesterase	-
DO80_RS04955	986414..986686	-	273	WP_015429138.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
DO80_RS04960	986673..986984	-	312	WP_108304246.1	hypothetical protein	Antitoxin
DO80_RS04970	987698..989929	-	2232	WP_149237385.1	Hop family adhesin BabA	-
DO80_RS04985	990312..990955	+	644	Protein_940	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10585.59 Da
• Isoelectric Point: 9.7265

>T32961 WP_015429138.1 NZ_AP019730:c986686-986414 [Helicobacter pylori]
MLMVETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Nucleotide

• Length: 273 bp

>T32961 NZ_AP019730:c986686-986414 [Helicobacter pylori]
ATGCTGATGGTTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGATCCCAAATACAAAGACCACCCGCTCAAAGGCGCTTTAA
AAGATTTTAGGGAATGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACCCTCTTTTTA
GTAAGGCTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12220.11 Da
• Isoelectric Point: 10.3595

>AT32961 WP_108304246.1 NZ_AP019730:c986984-986673 [Helicobacter pylori]
MPNTTAKKDYTKYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKHCENLRFKNADG

Nucleotide

• Length: 312 bp

>AT32961 NZ_AP019730:c986984-986673 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATTAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCCCTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGACACCAAGAACCAC
CTTTGTTTTAAAAGCGTAGAGGATTTTAAAAAGCATTGTGAGAACTTAAGATTTAAAAATGCTGATGGTTGA

Structures

Toxin

• AlphaFold DB: M4ZNL7