Detailed information of TA system TA032956

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 741131..741717
• Replicon: chromosome
• Accession: NZ_AP019720
• Organism: Streptococcus mutans strain NBRC 13955

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FNL60_RS03925
• Protein ID: WP_002265423.1
• Coordinates: 741131..741322 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0H5AQZ7
• Locus tag: FNL60_RS03930
• Protein ID: WP_002269450.1
• Coordinates: 741340..741717 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNL60_RS03910	739175..740041	+	867	WP_002280231.1	type II CRISPR-associated endonuclease Cas1	-
FNL60_RS03915	740038..740382	+	345	WP_002263547.1	CRISPR-associated endonuclease Cas2	-
FNL60_RS03920	740372..741034	+	663	WP_002263546.1	type II-A CRISPR-associated protein Csn2	-
FNL60_RS03925	741131..741322	+	192	WP_002265423.1	type II toxin-antitoxin system HicA family toxin	Toxin
FNL60_RS03930	741340..741717	+	378	WP_002269450.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FNL60_RS03935	741815..742108	-	294	WP_142366348.1	hypothetical protein	-
FNL60_RS03940	742187..743080	-	894	WP_002272311.1	LexA family transcriptional regulator IrvR	-
FNL60_RS03945	743396..743680	+	285	WP_002262720.1	helix-turn-helix transcriptional regulator	-
FNL60_RS03950	743843..745594	+	1752	WP_002279994.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-107)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7177.52 Da
• Isoelectric Point: 10.7089

>T32956 WP_002265423.1 NZ_AP019720:741131-741322 [Streptococcus mutans]
MPLTGKELARLAINNGWEEVRVRGSHHHFKKDGVPYIVTIPIHGNKVLKIGLEKKLLRDLNLL

Nucleotide

• Length: 192 bp

>T32956 NZ_AP019720:741131-741322 [Streptococcus mutans]
TTGCCATTAACAGGGAAAGAATTAGCTAGATTAGCGATAAACAATGGATGGGAAGAAGTTCGGGTGAGAGGAAGTCATCA
TCATTTCAAGAAAGATGGAGTACCTTATATTGTGACGATTCCCATTCATGGAAATAAAGTGCTTAAAATTGGTCTTGAAA
AGAAACTCTTAAGGGATTTAAATTTATTATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14293.28 Da
• Isoelectric Point: 4.5628

>AT32956 WP_002269450.1 NZ_AP019720:741340-741717 [Streptococcus mutans]
MLKSYPAIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGMKLPNPSEIRKLSVEDGFATMIQADP
NPYLKNNKAIRKNVTVPEWLVQLADRDQVNYSEVLTKALEKKLQL

Nucleotide

• Length: 378 bp

>AT32956 NZ_AP019720:741340-741717 [Streptococcus mutans]
ATGTTAAAATCATATCCTGCAATTTTTCATAAGGAAGAGGAAGGGTATTGGGTTGAATTTCCTGAATTTGGCGGTGGTAC
GCAAGGGGAAGATTTGGAAGAAGCCATGAAGAACGCTCGTCAGATGTTAGAAAGTGTATTGGCCTCCTATCTAGATGAGG
GAATGAAACTGCCTAATCCAAGTGAGATAAGGAAACTATCTGTTGAAGATGGCTTTGCAACTATGATTCAAGCAGATCCT
AATCCTTATCTCAAAAATAACAAAGCTATTCGAAAGAATGTTACCGTACCTGAGTGGCTAGTACAATTAGCAGATCGTGA
TCAAGTGAATTATTCTGAAGTATTAACAAAGGCTTTGGAAAAGAAACTACAATTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0H5AQZ7