Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 200446..201017 Replicon chromosome
Accession NZ_AP019720
Organism Streptococcus mutans strain NBRC 13955

Toxin (Protein)


Gene name mazF Uniprot ID A0A2J9QC66
Locus tag FNL60_RS01075 Protein ID WP_002265705.1
Coordinates 200685..201017 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q8DW96
Locus tag FNL60_RS01070 Protein ID WP_002262990.1
Coordinates 200446..200691 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNL60_RS01060 196353..198260 + 1908 WP_002280063.1 ATP-binding protein -
FNL60_RS01065 198280..199878 + 1599 WP_002280062.1 Abi family protein -
FNL60_RS01070 200446..200691 + 246 WP_002262990.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FNL60_RS01075 200685..201017 + 333 WP_002265705.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FNL60_RS01080 201215..202006 - 792 WP_002280060.1 nucleotidyltransferase domain-containing protein -
FNL60_RS10330 202173..202529 + 357 Protein_182 transposase family protein -
FNL60_RS01090 202708..203928 + 1221 WP_002270688.1 PTS sugar transporter subunit IIC -
FNL60_RS01095 203906..204754 + 849 WP_002280395.1 alpha/beta hydrolase -
FNL60_RS01100 204896..205498 + 603 WP_002280396.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 202173..202301 128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12664.56 Da        Isoelectric Point: 6.4634

>T32955 WP_002265705.1 NZ_AP019720:200685-201017 [Streptococcus mutans]
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIAIFAPISNTKRDYPFYVPLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Download         Length: 333 bp

>T32955 NZ_AP019720:200685-201017 [Streptococcus mutans]
ATGGTAACCATCAAGCAAGGGTCAATTATCAAAATTAACTTGGATCCCAAACAAGGACATGAACAAAAAGGGTATCGTCC
GTACATTTGTCTAAACCATAGTATCGTAACCAAGTATTCTAATATTGCTATTTTTGCGCCAATTAGCAATACCAAGCGTG
ATTACCCTTTTTATGTTCCCCTAGAAGGAACAGAATCCACAGGGAAAGTATTATTAGACCAACTGGTTACAATCGATTTT
AATGCTAGAGATTATCGTTATGTGGAGGATATTCAGGAAGACTTATTAGATGAACTTTTAGCTAGGGTCAAGGTGCTATT
TGAAAAAGGATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9241.52 Da        Isoelectric Point: 4.3021

>AT32955 WP_002262990.1 NZ_AP019720:200446-200691 [Streptococcus mutans]
MQLVINKWGNSSAIRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNIPELTVEDLFKDYQGEPVNVTPALFESVGNEQ
W

Download         Length: 246 bp

>AT32955 NZ_AP019720:200446-200691 [Streptococcus mutans]
ATGCAACTAGTCATCAATAAATGGGGAAATAGCTCCGCTATTCGTTTGCCAAAACAATTGGTACAAGAATTACAATTACA
AACAAATGATGTCTTAGACTATAAGGTATCAGGGAATAAAATTATCCTAGAAAAAGTGAATAATATCCCTGAATTAACTG
TAGAAGATCTGTTTAAAGATTATCAAGGTGAACCTGTCAATGTTACCCCAGCTCTATTTGAAAGTGTGGGAAATGAACAA
TGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QC66

Antitoxin

Source ID Structure
AlphaFold DB Q8DW96

References