Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 187863..188414 Replicon chromosome
Accession NZ_AP019720
Organism Streptococcus mutans strain NBRC 13955

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FNL60_RS01010 Protein ID WP_002280073.1
Coordinates 187863..188141 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FNL60_RS01015 Protein ID WP_002280072.1
Coordinates 188142..188414 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNL60_RS00975 183970..184224 - 255 WP_002270995.1 Txe/YoeB family addiction module toxin -
FNL60_RS00980 184217..184483 - 267 WP_002270994.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
FNL60_RS00985 184747..186405 - 1659 WP_002280077.1 transposase -
FNL60_RS00990 186412..186822 - 411 WP_002280076.1 DUF961 family protein -
FNL60_RS00995 186845..187159 - 315 WP_000406626.1 hypothetical protein -
FNL60_RS01005 187498..187734 - 237 WP_002280074.1 hypothetical protein -
FNL60_RS01010 187863..188141 - 279 WP_002280073.1 type II toxin-antitoxin system YafQ family toxin Toxin
FNL60_RS01015 188142..188414 - 273 WP_002280072.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FNL60_RS01020 188566..189279 + 714 WP_002280071.1 hypothetical protein -
FNL60_RS01025 190044..190406 + 363 WP_002280070.1 helix-turn-helix transcriptional regulator -
FNL60_RS01030 190413..191264 + 852 WP_002280069.1 ImmA/IrrE family metallo-endopeptidase -
FNL60_RS01035 191284..191646 - 363 WP_002280068.1 hypothetical protein -
FNL60_RS01040 191734..193284 - 1551 WP_002280067.1 DNA cytosine methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-68)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10924.78 Da        Isoelectric Point: 8.0384

>T32954 WP_002280073.1 NZ_AP019720:c188141-187863 [Streptococcus mutans]
MYQVKFTSAFKKSYKRIKKRGLEMTLLDEVIEKLRLGQTLEEKYRDHELKGNFVGFRECHIKPDWLLIYLIEDDILTLTL
ADTGSHADLFKM

Download         Length: 279 bp

>T32954 NZ_AP019720:c188141-187863 [Streptococcus mutans]
ATGTACCAAGTCAAGTTCACCTCTGCTTTTAAAAAGAGCTACAAACGGATTAAAAAGCGAGGCTTAGAGATGACACTCTT
AGATGAAGTGATTGAAAAACTCCGCCTAGGACAGACACTAGAAGAAAAATACCGTGACCATGAACTCAAAGGAAACTTTG
TTGGCTTTAGGGAATGCCACATCAAGCCAGATTGGCTCTTGATTTATCTGATTGAAGATGATATTTTGACATTGACTTTA
GCTGATACAGGCAGTCATGCGGATTTGTTTAAGATGTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9847.31 Da        Isoelectric Point: 5.0337

>AT32954 WP_002280072.1 NZ_AP019720:c188414-188142 [Streptococcus mutans]
MATVPTQIRIDETVKAQATSLFNDLGMDMSSAVNIFLRQCLLRGGLPFTVEVPNYSQKTLEALAEAKRISRDETVASYGN
LADLKKALEA

Download         Length: 273 bp

>AT32954 NZ_AP019720:c188414-188142 [Streptococcus mutans]
ATGGCAACTGTTCCAACGCAAATTCGGATTGATGAAACTGTCAAAGCCCAAGCAACTTCATTATTTAATGACTTGGGGAT
GGATATGTCTAGTGCGGTCAATATTTTTCTTCGTCAATGTCTATTGCGTGGTGGACTTCCTTTCACGGTTGAAGTCCCCA
ATTATAGCCAAAAGACCTTAGAAGCTCTGGCAGAAGCTAAGCGTATTTCTCGTGATGAAACGGTCGCTTCTTATGGCAAT
CTAGCAGATTTAAAGAAGGCTCTGGAAGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References