Detailed information of TA system TA032952

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): SmuAT/-
• Location: 169217..170178
• Replicon: chromosome
• Accession: NZ_AP019720
• Organism: Streptococcus mutans strain NBRC 13955

Toxin (Protein)

• Gene name: smuT
• Uniprot ID: A0A2J9QC39
• Locus tag: FNL60_RS00870
• Protein ID: WP_002267097.1
• Coordinates: 169217..169732 (+)
• Length: 172 a.a.

Antitoxin (Protein)

• Gene name: smuA
• Uniprot ID: -
• Locus tag: FNL60_RS00875
• Protein ID: WP_002267098.1
• Coordinates: 169732..170178 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNL60_RS00845	164634..165371	+	738	WP_002273490.1	MerR family transcriptional regulator	-
FNL60_RS00850	165407..166399	-	993	WP_002280090.1	BtrH N-terminal domain-containing protein	-
FNL60_RS00855	166588..167142	-	555	Protein_138	helix-turn-helix transcriptional regulator	-
FNL60_RS00860	167455..168201	+	747	WP_002264862.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-
FNL60_RS00865	168225..169085	+	861	WP_002267096.1	DegV family protein	-
FNL60_RS00870	169217..169732	+	516	WP_002267097.1	hypothetical protein	Toxin
FNL60_RS00875	169732..170178	+	447	WP_002267098.1	hypothetical protein	Antitoxin
FNL60_RS00880	170175..170369	+	195	WP_002267099.1	helix-turn-helix transcriptional regulator	-
FNL60_RS00890	170769..171215	+	447	WP_002262993.1	50S ribosomal protein L13	-
FNL60_RS00895	171240..171632	+	393	WP_002262992.1	30S ribosomal protein S9	-
FNL60_RS00900	171738..172961	-	1224	WP_002280089.1	tyrosine-type recombinase/integrase	-
FNL60_RS00905	173016..173288	-	273	WP_002280088.1	helix-turn-helix domain-containing protein	-
FNL60_RS00910	173400..173732	-	333	WP_002280087.1	type II toxin-antitoxin system PemK/MazF family toxin	-
FNL60_RS00915	173719..174024	-	306	WP_002280086.1	hypothetical protein	-
FNL60_RS00920	174081..175136	-	1056	WP_002271006.1	CHAP domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-65)

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 19512.16 Da
• Isoelectric Point: 9.8653

>T32952 WP_002267097.1 NZ_AP019720:169217-169732 [Streptococcus mutans]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKKFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK

Nucleotide

• Length: 516 bp

>T32952 NZ_AP019720:169217-169732 [Streptococcus mutans]
ATGTTTGACCTTGTTGTTAATTTGATTTTATTGGTTATTGTGATAGGTGGATTTGTCTTCTTAAGATTCTATGCGGATAA
GAAAGGCAAGCGAGAATACGATGAACGCCAGTTACTTATGCAAAAGAAAGCTTATACCAATGCGGCTTGGGTTGTTATGG
GTTTCAATCTTGTTCTTGTGATATGGGGTGAAGTGTTAGCAAAATATATCTCGCTATCCTTTGCAGGTACTGCCAATCTC
TTTCTTATCGTAGGCGTCTTTGTCTGTAGCAGTATCTTAAACGATGCTTATTTCACAGCAAGAAAAAACAAAAAATTCCT
CTATGTGTATGCCGTTATTATTGCTATTCAAATTTTCACTGTTTATCAAAATTGGAGTCAAGGCAGCTTTGGTCATGACG
GACATATTTATCTAACAGGAGAAAAAGCAATGAGTTTATTGTTTATCTTGACTTTTGCTGTCATTTTTCTAGTAACTGCT
TATAAAACGATTCAGGATAAGAGAGAGGGAAAGTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 17012.29 Da
• Isoelectric Point: 9.5767

>AT32952 WP_002267098.1 NZ_AP019720:169732-170178 [Streptococcus mutans]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRETITKCSYLGLSGFWLICMGASIVYRHYLDKKEADK

Nucleotide

• Length: 447 bp

>AT32952 NZ_AP019720:169732-170178 [Streptococcus mutans]
ATGAAAATGGAAAAGTCAAATAAACAAGTCATTTACGATGAACGTCAGCAGCAAATTCAACTTAAAAGTTATAGTCTTTC
ATTTTGGTTTGTTATGTTTATACTCTATTTTGCAACTTTTGGAAAGACTGATTTGTTGCTTAATATCGCTTTTTGGGGAG
GACTTGTTCTTAATTTTTGTTACAGTACTCTAAGAGGTGTCGGTCCTTTTGTTGATCCACGTTTTGGAAAAATTGCAAAA
ATCGGTCGTTTGGCCGCTGTTCCTCTTATTTTTTTGGGAATGCTAGTCTTTCTTGTTGCTATCATAATGTCTATTCTAGA
ACATGATAGTTTAAGAGAAACGATCACAAAATGCTCCTACTTAGGCTTATCTGGTTTTTGGCTAATTTGTATGGGAGCAA
GTATCGTCTACCGTCATTATCTTGATAAGAAAGAAGCAGACAAATGA

Structures

Toxin

• AlphaFold DB: A0A2J9QC39