Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2121836..2122350 Replicon chromosome
Accession NZ_AP019712
Organism Staphylococcus aureus strain Tokyo12480

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag GOZ34_RS10415 Protein ID WP_000581792.1
Coordinates 2121836..2122045 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag GOZ34_RS10420 Protein ID WP_000138932.1
Coordinates 2122057..2122350 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ34_RS10395 2117344..2118702 - 1359 WP_070974397.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
GOZ34_RS10400 2118717..2119787 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
GOZ34_RS10405 2120105..2121307 + 1203 WP_001109939.1 rod shape-determining protein RodA -
GOZ34_RS10410 2121571..2121708 - 138 WP_000828354.1 hypothetical protein -
GOZ34_RS10415 2121836..2122045 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
GOZ34_RS10420 2122057..2122350 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
GOZ34_RS10425 2122516..2124000 + 1485 WP_000571550.1 cardiolipin synthase -
GOZ34_RS10430 2124028..2124675 + 648 WP_001187614.1 HD domain-containing protein -
GOZ34_RS10435 2124955..2125254 + 300 WP_072435137.1 hypothetical protein -
GOZ34_RS10440 2125411..2126283 - 873 WP_000725800.1 membrane protein insertase YidC -
GOZ34_RS10445 2126369..2127010 - 642 WP_000483161.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T32924 WP_000581792.1 NZ_AP019712:c2122045-2121836 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T32924 NZ_AP019712:c2122045-2121836 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT32924 WP_000138932.1 NZ_AP019712:c2122350-2122057 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT32924 NZ_AP019712:c2122350-2122057 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References