Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 843347..843823 Replicon chromosome
Accession NZ_AP019712
Organism Staphylococcus aureus strain Tokyo12480

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag GOZ34_RS03960 Protein ID WP_000052076.1
Coordinates 843347..843535 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag GOZ34_RS03965 Protein ID WP_001059690.1
Coordinates 843563..843823 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOZ34_RS03930 839301..839858 + 558 WP_103147194.1 hypothetical protein -
GOZ34_RS03935 840199..840885 + 687 WP_155978041.1 thermonuclease family protein -
GOZ34_RS03940 841242..841442 + 201 WP_001059082.1 cold-shock protein -
GOZ34_RS03945 841939..842157 - 219 WP_000005880.1 hypothetical protein -
GOZ34_RS03950 842218..842502 - 285 WP_155978043.1 hypothetical protein -
GOZ34_RS03955 842590..843159 - 570 WP_155978045.1 hypothetical protein -
GOZ34_RS03960 843347..843535 - 189 WP_000052076.1 hypothetical protein Toxin
GOZ34_RS03965 843563..843823 - 261 WP_001059690.1 hypothetical protein Antitoxin
GOZ34_RS03970 844165..844368 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
GOZ34_RS03975 844365..844601 - 237 WP_000368687.1 hypothetical protein -
GOZ34_RS03980 844826..845407 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
GOZ34_RS03985 845480..846097 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
GOZ34_RS03990 846253..846747 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
GOZ34_RS03995 847146..847568 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
GOZ34_RS04000 847716..848432 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-111)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T32916 WP_000052076.1 NZ_AP019712:c843535-843347 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T32916 NZ_AP019712:c843535-843347 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT32916 WP_001059690.1 NZ_AP019712:c843823-843563 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT32916 NZ_AP019712:c843823-843563 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References