Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 4697906..4698579 Replicon chromosome
Accession NZ_AP019700
Organism Stella humosa strain ATCC 43930

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag STVA_RS22015 Protein ID WP_197735708.1
Coordinates 4697906..4698346 (-) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag STVA_RS22020 Protein ID WP_123692895.1
Coordinates 4698346..4698579 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STVA_RS21995 4694138..4695349 + 1212 WP_123692127.1 MFS transporter -
STVA_RS22000 4695365..4697044 + 1680 WP_123692129.1 amidohydrolase family protein -
STVA_RS22005 4697048..4697293 - 246 WP_197735707.1 hypothetical protein -
STVA_RS22010 4697430..4697909 + 480 WP_123692131.1 Lrp/AsnC family transcriptional regulator -
STVA_RS22015 4697906..4698346 - 441 WP_197735708.1 PIN domain-containing protein Toxin
STVA_RS22020 4698346..4698579 - 234 WP_123692895.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
STVA_RS22025 4698779..4699204 + 426 WP_123692133.1 DoxX family protein -
STVA_RS22030 4699262..4700299 - 1038 WP_170216577.1 WD40 repeat domain-containing protein -
STVA_RS22035 4700283..4701338 - 1056 WP_123692137.1 GTP-binding protein -
STVA_RS22040 4701420..4702295 - 876 WP_123692139.1 LysR family transcriptional regulator -
STVA_RS22045 4702393..4703250 + 858 WP_123692141.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(12-121)

Antitoxin

SpoVT-AbrB domain

(5-39)


Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16229.62 Da        Isoelectric Point: 6.4637

>T32915 WP_197735708.1 NZ_AP019700:c4698346-4697906 [Stella humosa]
MTGPHLLLSQNFFDTNVLLYLISKDTAKAGRAEELMASGGTISTQVLNEFASVAFRKGRLSWLEIREVLSTIRRLCRVTT
IDVDMHDEAIRIAERYRFSFYDALIVAAALSAGCSTLYTEDLNDGQLIEAVTVRNPFTSPAKRPLA

Download         Length: 441 bp

>T32915 NZ_AP019700:c4698346-4697906 [Stella humosa]
ATGACGGGGCCACACCTGCTGCTATCGCAGAATTTCTTCGATACCAACGTGCTACTCTATTTGATATCGAAGGACACAGC
CAAGGCAGGCCGGGCAGAGGAACTGATGGCCTCCGGTGGCACGATCAGCACTCAGGTCTTGAATGAATTTGCGTCGGTTG
CATTCCGAAAAGGTCGGCTAAGCTGGCTGGAAATCCGTGAGGTCTTGTCGACTATCCGCAGGCTTTGTCGCGTAACGACC
ATTGATGTCGATATGCATGATGAAGCAATCCGGATCGCCGAGCGATACCGTTTCTCTTTCTACGATGCCCTGATCGTCGC
CGCTGCGCTTTCTGCCGGATGCTCGACGCTCTATACTGAGGATCTGAATGACGGGCAGTTGATAGAGGCGGTCACGGTCA
GGAATCCCTTCACGTCGCCCGCCAAGCGCCCGCTGGCCTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8711.89 Da        Isoelectric Point: 5.8580

>AT32915 WP_123692895.1 NZ_AP019700:c4698579-4698346 [Stella humosa]
VRIAKWGNSLAVRLPTAVVEALALAEGDEIDVHVLGERSLAVERPADTDALLQRLRKYRGRLPEDFRFDRLEANERS

Download         Length: 234 bp

>AT32915 NZ_AP019700:c4698579-4698346 [Stella humosa]
GTGCGGATTGCGAAATGGGGCAACAGTTTGGCGGTTCGTTTGCCGACGGCCGTGGTCGAGGCACTGGCTCTTGCGGAAGG
CGACGAGATCGACGTTCACGTTCTTGGTGAGCGAAGTCTCGCCGTCGAACGGCCCGCAGATACCGACGCATTGCTGCAGC
GCCTGCGAAAATATCGTGGCCGATTGCCGGAGGACTTCCGCTTCGATCGTTTGGAAGCAAACGAGCGGTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References