Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 906236..906762 Replicon chromosome
Accession NZ_AP019698
Organism Staphylococcus arlettae strain P2

Toxin (Protein)


Gene name mazF Uniprot ID A0A7V7SNP8
Locus tag SAP2_RS04305 Protein ID WP_002509017.1
Coordinates 906406..906762 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7V7VEP5
Locus tag SAP2_RS04300 Protein ID WP_002509016.1
Coordinates 906236..906406 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAP2_RS12850 902249..902536 + 288 WP_133173768.1 PH domain-containing protein -
SAP2_RS04280 902529..904025 + 1497 WP_142019507.1 PH domain-containing protein -
SAP2_RS04285 904018..904491 + 474 WP_021459211.1 PH domain-containing protein -
SAP2_RS04290 904534..904887 + 354 WP_002509014.1 holo-ACP synthase -
SAP2_RS04295 904999..906147 + 1149 WP_142019508.1 alanine racemase -
SAP2_RS04300 906236..906406 + 171 WP_002509016.1 hypothetical protein Antitoxin
SAP2_RS04305 906406..906762 + 357 WP_002509017.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SAP2_RS04310 907034..908035 + 1002 WP_142019509.1 PP2C family protein-serine/threonine phosphatase -
SAP2_RS04315 908118..908444 + 327 WP_002509019.1 anti-sigma factor antagonist -
SAP2_RS04320 908446..908925 + 480 WP_002509020.1 anti-sigma B factor RsbW -
SAP2_RS04325 908900..909670 + 771 WP_103387739.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13385.57 Da        Isoelectric Point: 10.2885

>T32908 WP_002509017.1 NZ_AP019698:906406-906762 [Staphylococcus arlettae]
MRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRT
LDKKRLKEKLTYLSEDKMKEVNIAIDISLGLHNNRHHK

Download         Length: 357 bp

>T32908 NZ_AP019698:906406-906762 [Staphylococcus arlettae]
ATGAGACGAGGAGACGTCTACTTAGCTGACTTATCACCAGTACAAGGGTCTGAACAAGGGGGAGTAAGACCAGTTGTAAT
TATTCAAAATGATACTGGTAATAAATATAGTCCTACCGTGATTGTAGCTGCAATCACTGGTAGGATAAATAAAGCTAAAA
TACCAACACATGTTGAAATTGAAAAGAAAAAGTATAAATTGGATAAGGATTCAGTTATATTACTTGAGCAGATTCGAACG
TTAGATAAAAAAAGATTAAAAGAAAAGTTAACATACTTATCAGAAGATAAAATGAAAGAAGTCAACATAGCAATTGACAT
AAGTTTAGGATTACATAATAATAGGCATCATAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6236.72 Da        Isoelectric Point: 3.8099

>AT32908 WP_002509016.1 NZ_AP019698:906236-906406 [Staphylococcus arlettae]
MPSFNQSRNHNIEQSLKEGYSQMADLNLSLAAEAFPFECEACDCNESYISASNTND

Download         Length: 171 bp

>AT32908 NZ_AP019698:906236-906406 [Staphylococcus arlettae]
ATGCCAAGTTTTAACCAAAGTAGAAATCATAACATAGAACAATCTTTAAAAGAAGGCTATTCCCAAATGGCTGATTTGAA
TCTCTCCCTTGCAGCAGAAGCTTTTCCATTCGAATGTGAAGCTTGTGATTGCAACGAATCATATATTAGTGCTAGTAACA
CTAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V7SNP8

Antitoxin

Source ID Structure
AlphaFold DB A0A7V7VEP5

References