Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 895121..895632 Replicon chromosome
Accession NZ_AP019698
Organism Staphylococcus arlettae strain P2

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7V7VCW3
Locus tag SAP2_RS04250 Protein ID WP_002509005.1
Coordinates 895426..895632 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A7V7SPC1
Locus tag SAP2_RS04245 Protein ID WP_002509004.1
Coordinates 895121..895414 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAP2_RS04225 890838..891473 + 636 WP_002509000.1 thiamine phosphate synthase -
SAP2_RS04230 891560..892426 + 867 WP_021459216.1 membrane protein insertase YidC -
SAP2_RS04235 892747..893412 - 666 WP_142019504.1 HD domain-containing protein -
SAP2_RS04240 893498..894982 - 1485 WP_142019505.1 cardiolipin synthase -
SAP2_RS04245 895121..895414 + 294 WP_002509004.1 copper-sensing transcriptional repressor CsoR Antitoxin
SAP2_RS04250 895426..895632 + 207 WP_002509005.1 hypothetical protein Toxin
SAP2_RS12845 895802..895942 + 141 WP_002509006.1 hypothetical protein -
SAP2_RS04255 895989..897185 - 1197 WP_002509007.1 rod shape-determining protein RodA -
SAP2_RS04260 897424..898494 + 1071 WP_112369528.1 D-alanine--D-alanine ligase -
SAP2_RS04265 898506..899861 + 1356 WP_142019506.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(24-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7723.91 Da        Isoelectric Point: 5.5509

>T32907 WP_002509005.1 NZ_AP019698:895426-895632 [Staphylococcus arlettae]
MESKVIFLAGLTSYKQQAQLTQKLLNIIGVHQVHVSLEKSIVQITFDTPANLNNIEKEIYDDGYTILF

Download         Length: 207 bp

>T32907 NZ_AP019698:895426-895632 [Staphylococcus arlettae]
ATGGAATCAAAAGTCATCTTTTTAGCGGGTTTAACGTCTTATAAACAACAAGCACAATTAACACAAAAATTGTTAAATAT
TATTGGAGTCCATCAAGTACACGTTAGCCTCGAGAAAAGTATTGTTCAGATTACATTTGATACACCAGCTAACTTAAATA
ATATCGAAAAAGAAATATATGATGATGGATATACCATTCTATTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11043.67 Da        Isoelectric Point: 6.8617

>AT32907 WP_002509004.1 NZ_AP019698:895121-895414 [Staphylococcus arlettae]
MTEVDKAHHSTQTKANLKSRLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNAGEQ
EAAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT32907 NZ_AP019698:895121-895414 [Staphylococcus arlettae]
ATGACAGAGGTAGACAAAGCGCATCATTCTACTCAGACAAAAGCCAATTTAAAATCACGTTTGAATCGTATAGAGGGGCA
AGTAAGAGCGATTAATAGAATGATTGATGAAGATGTTTATTGTGATGATGTCTTAACACAAATCAGAGCAACGCGTTCTG
CGTTAAACAGTGTTGCTACAAAATTATTAGATCATCATATGAAGAGCTGTATTATGGACAAAGTGAACGCGGGCGAGCAA
GAAGCGGCTATGGAAGAATTACTAGTAACATTTCAAAAGCTCATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V7VCW3

Antitoxin

Source ID Structure
AlphaFold DB A0A7V7SPC1

References