Detailed information of TA system TA032906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2238226..2238770
• Replicon: chromosome
• Accession: NZ_AP019697
• Organism: Dialister hominis strain 5BBH33

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: Dia5BBH33_RS10280
• Protein ID: WP_022381609.1
• Coordinates: 2238226..2238501 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: Dia5BBH33_RS10285
• Protein ID: WP_022381610.1
• Coordinates: 2238498..2238770 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Dia5BBH33_RS10240	2233962..2234189	-	228	WP_144269439.1	DUF4314 domain-containing protein	-
Dia5BBH33_RS10245	2234239..2234454	+	216	WP_144269286.1	hypothetical protein	-
Dia5BBH33_RS10250	2234443..2234877	-	435	WP_144269287.1	hypothetical protein	-
Dia5BBH33_RS10255	2234966..2235241	-	276	WP_144269288.1	prevent-host-death protein	-
Dia5BBH33_RS10260	2235243..2235791	-	549	WP_144269289.1	N-acetylmuramoyl-L-alanine amidase	-
Dia5BBH33_RS10265	2235791..2237020	-	1230	WP_144269290.1	DNA modification methylase	-
Dia5BBH33_RS10270	2237023..2237589	-	567	WP_144269291.1	P27 family phage terminase small subunit	-
Dia5BBH33_RS10275	2237719..2238099	-	381	WP_108850321.1	HNH endonuclease	-
Dia5BBH33_RS10280	2238226..2238501	-	276	WP_022381609.1	type II toxin-antitoxin system YafQ family toxin	Toxin
Dia5BBH33_RS10285	2238498..2238770	-	273	WP_022381610.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
Dia5BBH33_RS10290	2238953..2239413	-	461	Protein_2008	hypothetical protein	-
Dia5BBH33_RS10295	2239410..2240765	-	1356	WP_144269292.1	DEAD/DEAH box helicase	-
Dia5BBH33_RS10300	2240746..2241027	-	282	WP_144269293.1	VRR-NUC domain-containing protein	-
Dia5BBH33_RS10305	2241173..2241598	-	426	WP_048514386.1	hypothetical protein	-
Dia5BBH33_RS10310	2241615..2241854	-	240	WP_171969723.1	hypothetical protein	-
Dia5BBH33_RS10315	2241874..2242443	-	570	WP_144269294.1	DUF2815 family protein	-
Dia5BBH33_RS10320	2242436..2243578	-	1143	WP_144269295.1	DUF2800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2213281..2266236	52955

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-76)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10766.43 Da
• Isoelectric Point: 7.2406

>T32906 WP_022381609.1 NZ_AP019697:c2238501-2238226 [Dialister hominis]
MKYEVKFTTQFKKDLKLAKKQNKDIDVLFSVIEQLAQGKQLDEKYRDHDLGGTYKGCRECHIDPDWLLIYETKDDVLVLL
LYRLGSHSQLF

Nucleotide

• Length: 276 bp

>T32906 NZ_AP019697:c2238501-2238226 [Dialister hominis]
ATGAAGTACGAAGTAAAATTCACCACTCAATTTAAGAAAGATTTGAAATTGGCAAAGAAGCAGAACAAAGATATAGATGT
GCTGTTCTCTGTCATTGAGCAATTGGCCCAAGGAAAACAATTGGATGAAAAATATAGAGACCATGATTTAGGTGGAACAT
ACAAAGGTTGCCGGGAATGCCATATTGATCCAGATTGGCTTCTCATTTATGAAACCAAAGATGATGTACTTGTTCTTCTG
CTATATCGTTTGGGCAGTCATTCCCAATTATTTTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10153.81 Da
• Isoelectric Point: 10.5419

>AT32906 WP_022381610.1 NZ_AP019697:c2238770-2238498 [Dialister hominis]
MVNTNLNIRTDKEVKNQAEKIFNALGMNMTTAVNIFLKTTIRENGIPFRLTLDVPNATTRSAIEEGKRIAIDKKVKGYTN
MTDLRVALEK

Nucleotide

• Length: 273 bp

>AT32906 NZ_AP019697:c2238770-2238498 [Dialister hominis]
ATGGTAAATACAAATTTGAATATCCGGACGGATAAGGAAGTCAAAAATCAGGCTGAGAAAATATTCAATGCTCTGGGAAT
GAATATGACGACGGCGGTAAACATATTCTTAAAAACAACGATACGAGAAAATGGCATTCCCTTCCGTCTCACTCTTGACG
TTCCTAATGCAACAACTAGATCTGCCATTGAAGAAGGCAAACGAATCGCCATTGATAAAAAAGTAAAAGGGTATACCAAT
ATGACAGATTTGCGTGTGGCCCTTGAAAAATGA