Detailed information of TA system TA032905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH
• Location: 336364..336854
• Replicon: chromosome
• Accession: NZ_AP019695
• Organism: Amedibacterium intestinale strain N6H1-5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: Aargi30884_RS01805
• Protein ID: WP_174766916.1
• Coordinates: 336582..336854 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: Aargi30884_RS01800
• Protein ID: WP_115714654.1
• Coordinates: 336364..336582 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Aargi30884_RS01760	331828..332061	+	234	WP_147360222.1	hypothetical protein	-
Aargi30884_RS01765	332054..332335	+	282	WP_115714645.1	hypothetical protein	-
Aargi30884_RS01770	332337..332768	+	432	WP_115714646.1	hypothetical protein	-
Aargi30884_RS01775	333133..333771	-	639	WP_115714648.1	hypothetical protein	-
Aargi30884_RS01780	333821..334063	+	243	WP_115714649.1	helix-turn-helix domain-containing protein	-
Aargi30884_RS01785	334386..334754	+	369	WP_115714651.1	hypothetical protein	-
Aargi30884_RS01790	334799..335131	+	333	WP_115714652.1	hypothetical protein	-
Aargi30884_RS01795	335128..336081	+	954	WP_163051353.1	DUF5011 domain-containing protein	-
Aargi30884_RS01800	336364..336582	+	219	WP_115714654.1	CopG family transcriptional regulator	Antitoxin
Aargi30884_RS01805	336582..336854	+	273	WP_174766916.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	327525..396998	69473

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-88)

Antitoxin

• Protein of unknown function DUF6290 (2-69)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10782.71 Da
• Isoelectric Point: 10.3942

>T32905 WP_174766916.1 NZ_AP019695:336582-336854 [Amedibacterium intestinale]
MYQVHYSKKAFKQLEKLDVPTRKKIYSWISKNLVGCSDPYRVPNFKELKGDKRGYIRYRVGTYRIICEVINNELTILVIN
IGHRKEVYKK

Nucleotide

• Length: 273 bp

>T32905 NZ_AP019695:336582-336854 [Amedibacterium intestinale]
ATGTATCAGGTTCATTATTCAAAGAAAGCATTTAAGCAGCTAGAAAAATTAGATGTACCAACAAGGAAAAAGATTTATTC
TTGGATAAGTAAAAATCTTGTTGGCTGTTCAGATCCATACAGAGTTCCAAACTTTAAAGAGTTGAAAGGTGATAAGAGAG
GGTATATTCGATATCGTGTAGGAACATACAGGATCATTTGTGAGGTAATCAATAATGAGTTAACTATTTTGGTTATCAAT
ATTGGTCATAGAAAAGAAGTGTATAAAAAATAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8389.63 Da
• Isoelectric Point: 4.5317

>AT32905 WP_115714654.1 NZ_AP019695:336364-336582 [Amedibacterium intestinale]
MLSIRLNPQAEKELKEIAKFEGVSVSDYVRKIINEKLEDMYDMKLAEEAHMEYINDPETFSHDEVGKMLGIK

Nucleotide

• Length: 219 bp

>AT32905 NZ_AP019695:336364-336582 [Amedibacterium intestinale]
ATGTTATCAATCAGATTAAATCCACAGGCTGAAAAAGAACTTAAAGAAATTGCTAAATTTGAAGGTGTTAGTGTATCTGA
CTATGTTCGTAAAATTATCAATGAGAAACTGGAAGATATGTATGATATGAAGTTAGCAGAGGAAGCACATATGGAGTATA
TCAATGATCCTGAAACATTTTCACATGATGAAGTTGGAAAGATGCTGGGGATTAAATAA