Detailed information of TA system TA032904

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH
• Location: 165163..165632
• Replicon: chromosome
• Accession: NZ_AP019695
• Organism: Amedibacterium intestinale strain N6H1-5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: Aargi30884_RS00940
• Protein ID: WP_118278041.1
• Coordinates: 165381..165632 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: Aargi30884_RS00935
• Protein ID: WP_118278040.1
• Coordinates: 165163..165381 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Aargi30884_RS00900	160433..160675	+	243	WP_115714649.1	helix-turn-helix domain-containing protein	-
Aargi30884_RS00905	160998..161366	+	369	WP_118276910.1	hypothetical protein	-
Aargi30884_RS00910	161411..161686	+	276	WP_158572285.1	HU family DNA-binding protein	-
Aargi30884_RS00915	161688..162263	+	576	WP_118276908.1	hypothetical protein	-
Aargi30884_RS00920	162322..162852	+	531	WP_118276907.1	hypothetical protein	-
Aargi30884_RS00925	162867..163817	+	951	WP_163051262.1	DUF5011 domain-containing protein	-
Aargi30884_RS00930	163821..164765	+	945	WP_163051264.1	DUF5011 domain-containing protein	-
Aargi30884_RS00935	165163..165381	+	219	WP_118278040.1	CopG family transcriptional regulator	Antitoxin
Aargi30884_RS00940	165381..165632	+	252	WP_118278041.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• Protein of unknown function DUF6290 (2-69)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9807.56 Da
• Isoelectric Point: 10.5393

>T32904 WP_118278041.1 NZ_AP019695:165381-165632 [Amedibacterium intestinale]
MYQVHYSKKAFKQLEKLGVPTRKKIYSWISKNLVGCSDPYRVPNFKELKVDKRGYIRYRVGRHRGICEVINNELTILVIN
IGH

Nucleotide

• Length: 252 bp

>T32904 NZ_AP019695:165381-165632 [Amedibacterium intestinale]
ATGTATCAGGTTCATTATTCAAAGAAAGCATTTAAGCAGCTAGAAAAATTAGGTGTACCAACAAGGAAAAAGATTTATTC
CTGGATAAGTAAAAATCTTGTTGGCTGTTCAGATCCATACAGAGTTCCAAACTTTAAAGAGTTGAAAGTAGATAAGAGAG
GGTATATTCGATATCGTGTAGGAAGACACAGGGGCATTTGTGAGGTAATCAATAATGAGTTAACTATTTTAGTTATCAAT
ATTGGTCATTGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8341.58 Da
• Isoelectric Point: 5.1373

>AT32904 WP_118278040.1 NZ_AP019695:165163-165381 [Amedibacterium intestinale]
MLSIRLNPQAEKELKEIAKFEGVSVSDYVRKIINEKLEDMYDMKLAEEAHMGYINNPETFSHDEVGKRLGIK

Nucleotide

• Length: 219 bp

>AT32904 NZ_AP019695:165163-165381 [Amedibacterium intestinale]
ATGTTATCAATCAGATTAAATCCACAGGCTGAAAAAGAACTTAAAGAAATTGCTAAATTTGAAGGTGTTAGTGTATCTGA
CTATGTTCGTAAAATTATCAATGAGAAACTGGAAGATATGTATGATATGAAGTTAGCAGAGGAAGCACATATGGGGTATA
TCAATAATCCTGAAACGTTTTCACATGATGAAGTTGGTAAGAGGCTGGGGATTAAATAA