Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 159296..160035 Replicon plasmid pGSH0205-8M-1-1
Accession NZ_AP019670
Organism Raoultella ornithinolytica strain GSH0205-8M-1

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag QMG92_RS26735 Protein ID WP_076752153.1
Coordinates 159550..160035 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A5E1AWX8
Locus tag QMG92_RS26730 Protein ID WP_012540086.1
Coordinates 159296..159562 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG92_RS26700 (ROGSH02058M1_p11680) 154526..155062 - 537 WP_013087166.1 GNAT family N-acetyltransferase -
QMG92_RS26705 (ROGSH02058M1_p11690) 155187..156944 - 1758 WP_137055842.1 arsenical pump-driving ATPase -
QMG92_RS26710 (ROGSH02058M1_p11700) 156965..157327 - 363 WP_013087168.1 arsenic metallochaperone ArsD family protein -
QMG92_RS26715 (ROGSH02058M1_p11710) 157403..157948 - 546 WP_047365773.1 sigma-70 family RNA polymerase sigma factor -
QMG92_RS26720 (ROGSH02058M1_p11720) 157957..158670 - 714 WP_013087170.1 arsenical resistance protein ArsH -
QMG92_RS26725 (ROGSH02058M1_p11730) 158672..158995 - 324 WP_013087171.1 metalloregulator ArsR/SmtB family transcription factor -
QMG92_RS26730 (ROGSH02058M1_p11740) 159296..159562 + 267 WP_012540086.1 DUF1778 domain-containing protein Antitoxin
QMG92_RS26735 (ROGSH02058M1_p11750) 159550..160035 + 486 WP_076752153.1 GNAT family N-acetyltransferase Toxin
QMG92_RS26740 (ROGSH02058M1_p11760) 160319..160471 + 153 WP_223526259.1 DUF5431 family protein -
QMG92_RS26745 160416..160535 + 120 WP_223156217.1 type I toxin-antitoxin system Hok family toxin -
QMG92_RS26750 (ROGSH02058M1_p11770) 161394..161720 + 327 WP_076752150.1 hypothetical protein -
QMG92_RS26755 (ROGSH02058M1_p11780) 161828..162040 + 213 WP_076752148.1 hypothetical protein -
QMG92_RS26760 (ROGSH02058M1_p11790) 162190..162501 + 312 WP_076752146.1 type II toxin-antitoxin system HigB family toxin -
QMG92_RS26765 (ROGSH02058M1_p11800) 162498..162914 + 417 WP_076752145.1 helix-turn-helix domain-containing protein -
QMG92_RS26770 (ROGSH02058M1_p11820) 163804..164076 + 273 WP_137055850.1 hypothetical protein -
QMG92_RS26775 (ROGSH02058M1_p11830) 164179..164526 + 348 WP_076752140.1 hypothetical protein -
QMG92_RS26780 (ROGSH02058M1_p11840) 164615..164845 + 231 WP_076752138.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaNDM-5 - 1..241445 241445


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-152)

Antitoxin

(2-87)


Sequences


Toxin        


Download         Length: 162 a.a.        Molecular weight: 17838.68 Da        Isoelectric Point: 10.0748

>T32859 WP_076752153.1 NZ_AP019670:159550-160035 [Raoultella ornithinolytica]
VGRVTVPEPLSSFHQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSRTQQRTLFLKLP
Q

Download         Length: 486 bp

>T32859 NZ_AP019670:159550-160035 [Raoultella ornithinolytica]
GTGGGACGTGTAACAGTACCAGAACCTTTATCCAGCTTTCATCAGGTGGCGGAATTCGTTTGCGGTGAAACTGTTCTGGA
TGACTGGTTAAAGCAGAAAGGCCTCAAAAACCAGGCTCTCGGATCGGCCAGAACGTTTGTAGTGTGTAAAAAAGACACGA
AACAAGTAGCCGGTTTTTACTCTCTGGCCACCGGGAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCCGATCCCATCCCTGTTATTATACTTGCCCGTCTTGCTGTCGATCTCTCTTTCCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTCACCG
AAGAAGCTAAAAATTTCTACATTCACCATGGTTTCAAACCATCACGAACTCAGCAACGGACATTATTTCTTAAACTCCCT
CAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10076.47 Da        Isoelectric Point: 4.3721

>AT32859 WP_012540086.1 NZ_AP019670:159296-159562 [Raoultella ornithinolytica]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT32859 NZ_AP019670:159296-159562 [Raoultella ornithinolytica]
ATGAAATCAGATGTTCAACTTAATCTTAGAGCAAAGGAATCACAGCGGGCGCTCATTGATGCTGCTGCGGAAATTCTTCA
CAAATCACGAACAGACTTCATCCTGGAAATGGCCTGTCAGGCCGCTGAGAACGTGATCCTCGATCGCCGGGTCTTTAATT
TTAACGATGAACAATATGCCGAATTCATCGACATGCTTGATGCCCCTGTTGCAGATGATCCTGCCATAGATAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AWX8

References