Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4795857..4796421 Replicon chromosome
Accession NZ_AP019669
Organism Raoultella ornithinolytica strain GSH0205-8M-1

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag QMG92_RS22690 Protein ID WP_183114417.1
Coordinates 4796146..4796421 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag QMG92_RS22685 Protein ID WP_113991318.1
Coordinates 4795857..4796159 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG92_RS22670 (ROGSH02058M1_044430) 4791799..4792134 + 336 WP_183114416.1 endoribonuclease SymE -
QMG92_RS22675 (ROGSH02058M1_044440) 4792367..4794439 + 2073 WP_228287659.1 AAA family ATPase -
QMG92_RS22680 (ROGSH02058M1_044450) 4794439..4795761 + 1323 WP_162661703.1 restriction endonuclease -
QMG92_RS22685 (ROGSH02058M1_044460) 4795857..4796159 - 303 WP_113991318.1 BrnA antitoxin family protein Antitoxin
QMG92_RS22690 (ROGSH02058M1_044470) 4796146..4796421 - 276 WP_183114417.1 BrnT family toxin Toxin
QMG92_RS22695 (ROGSH02058M1_044480) 4796538..4796957 - 420 WP_004857515.1 FosA family fosfomycin resistance glutathione transferase -
QMG92_RS22700 (ROGSH02058M1_044490) 4796951..4797859 - 909 WP_004857513.1 LysR family transcriptional regulator -
QMG92_RS22705 (ROGSH02058M1_044500) 4797947..4798729 + 783 WP_104896592.1 NAD(P)H-dependent oxidoreductase -
QMG92_RS22710 (ROGSH02058M1_044510) 4798877..4799455 + 579 WP_113991322.1 TetR/AcrR family transcriptional regulator -
QMG92_RS22715 (ROGSH02058M1_044520) 4799599..4800411 + 813 WP_183114418.1 winged helix-turn-helix domain-containing protein -
QMG92_RS22720 (ROGSH02058M1_044530) 4800408..4800926 + 519 WP_015585229.1 FidL-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-87)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(35-93)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10587.95 Da        Isoelectric Point: 7.0737

>T32857 WP_183114417.1 NZ_AP019669:c4796421-4796146 [Raoultella ornithinolytica]
MPMEFEWDANKAASNLRKHGIRFEEAVLVFNDPQHLSRHDRYENGEYRWQTIGLVHGVIVVLVAHSIRFESGTEVIRIIS
ARKADKNYEHG

Download         Length: 276 bp

>T32857 NZ_AP019669:c4796421-4796146 [Raoultella ornithinolytica]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCAGCAAGCAATCTAAGAAAACATGGGATTCGCTTCGAGGAGGCGGT
ACTGGTTTTTAACGATCCGCAGCATCTTTCCCGACATGATCGCTATGAAAATGGTGAGTATCGATGGCAAACCATCGGGC
TTGTTCATGGCGTGATTGTTGTTCTTGTGGCGCATTCGATCCGTTTTGAAAGTGGAACGGAGGTCATTCGTATTATCAGC
GCCCGGAAGGCGGACAAAAATTATGAGCATGGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11539.05 Da        Isoelectric Point: 7.0165

>AT32857 WP_113991318.1 NZ_AP019669:c4796159-4795857 [Raoultella ornithinolytica]
MSMVKHKRDNPTALTAQREDELKALAKKSDDDIDYSDIPSSDDEPWSEAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMIRDLSEK

Download         Length: 303 bp

>AT32857 NZ_AP019669:c4796159-4795857 [Raoultella ornithinolytica]
ATGAGCATGGTTAAACATAAACGCGATAACCCGACAGCGCTTACCGCTCAGCGTGAAGACGAACTCAAAGCGCTGGCGAA
AAAATCAGATGATGACATTGATTACAGCGATATCCCCTCTTCGGACGATGAGCCGTGGTCAGAGGCGGTTCGTGGTAAAT
TTTATCGGCCATTAAAAACGCAGGCCTCTGTGCGCATCGATGCAGATGTGATGGAGTGGCTTAAACGCCCGGGAAAAGGC
TATCAAACGCGGCTGAACGCGATTTTAAGAGAAGCGATGATTCGCGATCTGAGCGAGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References