Detailed information of TA system TA032853

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2422836..2423749
• Replicon: chromosome
• Accession: NZ_AP019669
• Organism: Raoultella ornithinolytica strain GSH0205-8M-1

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A808Y4A8
• Locus tag: QMG92_RS11325
• Protein ID: WP_015584188.1
• Coordinates: 2422836..2423309 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: QMG92_RS11330
• Protein ID: WP_032716402.1
• Coordinates: 2423306..2423749 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG92_RS11300 (ROGSH02058M1_022100)	2418875..2419483	-	609	WP_075808479.1	glutathione S-transferase family protein	-
QMG92_RS11305 (ROGSH02058M1_022120)	2419725..2420630	+	906	WP_054829296.1	transcriptional regulator GcvA	-
QMG92_RS11310 (ROGSH02058M1_022130)	2420658..2421563	-	906	WP_044349852.1	LysR family transcriptional regulator	-
QMG92_RS11315 (ROGSH02058M1_022140)	2421666..2421983	+	318	WP_004862785.1	nuclear transport factor 2 family protein	-
QMG92_RS11320 (ROGSH02058M1_022150)	2421976..2422755	+	780	WP_183114610.1	SDR family oxidoreductase	-
QMG92_RS11325 (ROGSH02058M1_022160)	2422836..2423309	-	474	WP_015584188.1	RES domain-containing protein	Toxin
QMG92_RS11330 (ROGSH02058M1_022170)	2423306..2423749	-	444	WP_032716402.1	DUF2384 domain-containing protein	Antitoxin
QMG92_RS11335 (ROGSH02058M1_022180)	2423939..2424505	-	567	WP_183114611.1	DJ-1/PfpI family protein	-
QMG92_RS11340 (ROGSH02058M1_022190)	2424903..2425685	+	783	WP_032717546.1	DUF3750 domain-containing protein	-
QMG92_RS11345 (ROGSH02058M1_022200)	2425881..2427104	+	1224	WP_183114612.1	zinc metallochaperone GTPase ZigA	-
QMG92_RS11365	2428033..2428509	-	477	WP_071887178.1	acid resistance repetitive basic protein Asr	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (95-144)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17524.82 Da
• Isoelectric Point: 4.8081

>T32853 WP_015584188.1 NZ_AP019669:c2423309-2422836 [Raoultella ornithinolytica]
MIFYRLVTGRYASEAWTGSGANQYGGRWNHQGHPAVYVSTSIALASLEILVHVKNEAILNQYQLYSIEIPDSEVESLDKQ
WLPDNWQENPMPVSTMDLGTGWLQSGSGLALMLPSCIIPYENNAILNPLHPAFSEALASVRQYPFTFDPRLARSTPL

Nucleotide

• Length: 474 bp

>T32853 NZ_AP019669:c2423309-2422836 [Raoultella ornithinolytica]
ATGATTTTCTATCGTCTGGTTACCGGCCGTTACGCCAGCGAAGCCTGGACGGGAAGCGGGGCCAACCAGTACGGCGGGCG
CTGGAATCACCAGGGACACCCGGCGGTCTATGTGTCCACTTCCATTGCCCTGGCGTCACTGGAGATCCTGGTTCACGTCA
AAAATGAGGCAATCCTCAACCAGTATCAGCTGTATAGTATCGAGATACCGGACAGTGAAGTGGAATCCCTCGATAAACAG
TGGTTACCGGATAACTGGCAAGAAAATCCGATGCCCGTTTCCACAATGGATCTGGGCACCGGCTGGCTACAGTCGGGCAG
CGGTCTGGCGCTGATGCTTCCCTCCTGCATTATTCCCTATGAAAACAACGCCATTTTAAACCCGCTGCATCCCGCGTTCA
GCGAGGCCCTGGCCTCCGTGCGTCAGTATCCCTTTACCTTTGATCCCCGCCTCGCACGCTCCACGCCCCTCTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16176.42 Da
• Isoelectric Point: 4.9405

>AT32853 WP_032716402.1 NZ_AP019669:c2423749-2423306 [Raoultella ornithinolytica]
MKTWVPAEQPADNALWRYAGLPANRGMQLIELLSMGLPVSVLDNIHEWTEMSKTDILRITGINERNVARRKSAGGTLTPG
ESERVARFVRVLDTAVDYFGSKQDAYDWLQSPVRGLGNVAPIDLIATESGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT32853 NZ_AP019669:c2423749-2423306 [Raoultella ornithinolytica]
ATGAAAACCTGGGTTCCTGCAGAGCAACCTGCCGATAATGCGCTGTGGCGCTATGCCGGGCTACCGGCGAATCGGGGTAT
GCAGTTGATTGAGCTGCTGAGTATGGGATTACCGGTCAGCGTTCTGGATAATATTCATGAGTGGACGGAAATGTCGAAAA
CCGACATTCTGCGCATCACCGGGATTAATGAGCGCAACGTTGCCCGGCGCAAGAGCGCGGGCGGCACGTTGACGCCAGGC
GAAAGCGAACGTGTGGCGCGTTTTGTCAGGGTCCTGGATACCGCCGTCGACTATTTTGGCAGCAAGCAGGATGCCTACGA
CTGGCTGCAGTCGCCGGTCAGAGGACTGGGCAATGTCGCCCCCATCGATCTGATTGCTACCGAGAGCGGCGCGCTGGAAG
TAACAGACCTGATTGGTCGCCTGGAACACGGCGTCTTTGCATGA

Structures

Toxin

• AlphaFold DB: A0A808Y4A8