Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 877296..877953 Replicon chromosome
Accession NZ_AP019669
Organism Raoultella ornithinolytica strain GSH0205-8M-1

Toxin (Protein)


Gene name cptA Uniprot ID A0A808XTM6
Locus tag QMG92_RS04220 Protein ID WP_004867355.1
Coordinates 877543..877953 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A514ELX1
Locus tag QMG92_RS04215 Protein ID WP_004867358.1
Coordinates 877296..877562 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG92_RS04190 (ROGSH02058M1_008230) 872431..873864 - 1434 WP_004867372.1 6-phospho-beta-glucosidase -
QMG92_RS04195 (ROGSH02058M1_008240) 873984..874712 - 729 WP_004867368.1 MurR/RpiR family transcriptional regulator -
QMG92_RS04200 (ROGSH02058M1_008250) 874762..875073 + 312 WP_004867365.1 N(4)-acetylcytidine aminohydrolase -
QMG92_RS04205 (ROGSH02058M1_008260) 875235..875894 + 660 WP_004867362.1 hemolysin III family protein -
QMG92_RS04210 (ROGSH02058M1_008270) 876016..876999 - 984 WP_015585783.1 tRNA-modifying protein YgfZ -
QMG92_RS04215 (ROGSH02058M1_008280) 877296..877562 + 267 WP_004867358.1 FAD assembly factor SdhE Antitoxin
QMG92_RS04220 (ROGSH02058M1_008290) 877543..877953 + 411 WP_004867355.1 protein YgfX Toxin
QMG92_RS04225 (ROGSH02058M1_008300) 877961..878482 - 522 WP_004867353.1 flavodoxin FldB -
QMG92_RS04230 (ROGSH02058M1_008310) 878660..879556 + 897 WP_032718225.1 site-specific tyrosine recombinase XerD -
QMG92_RS04235 (ROGSH02058M1_008320) 879579..880292 + 714 WP_004867349.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QMG92_RS04240 (ROGSH02058M1_008330) 880298..882031 + 1734 WP_064356671.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16226.16 Da        Isoelectric Point: 11.3349

>T32842 WP_004867355.1 NZ_AP019669:877543-877953 [Raoultella ornithinolytica]
VVLWQSDLRISWRSQWFSLLLHGIVAAIVLLMPWPLSYTPLWLLLLSLVVFDSVRSQRRIHACRGEIKLMTDSRLRWQKA
EWEIVGTPWVINSGMLLRLQDMQTRRRQHLWIAADSMDAKEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T32842 NZ_AP019669:877543-877953 [Raoultella ornithinolytica]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCCTGGCGCTCACAGTGGTTCTCGCTGCTGCTGCACGGCATTGTGGCGGC
TATTGTGCTGCTGATGCCCTGGCCGCTGAGCTACACGCCGCTATGGCTATTGCTGCTGTCGCTGGTGGTGTTCGACAGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCGGGGGGAAATAAAGCTGATGACCGATTCGCGTTTGCGTTGGCAAAAAGCG
GAATGGGAGATTGTCGGCACGCCGTGGGTGATTAATAGCGGGATGTTGCTGCGTCTGCAGGATATGCAAACGCGTCGCCG
CCAGCATCTGTGGATCGCTGCAGACAGTATGGACGCCAAAGAGTGGCGAGATCTGCGCCGGTTGGTGTTACAAAAACCGG
CACAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10553.05 Da        Isoelectric Point: 4.8432

>AT32842 WP_004867358.1 NZ_AP019669:877296-877562 [Raoultella ornithinolytica]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKQLFIRLLENDDPDLFNWLMNHGEPADAQLQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT32842 NZ_AP019669:877296-877562 [Raoultella ornithinolytica]
ATGGACATTACGAATAAAGCCCGCATCCACTGGGCATGCCGCAGGGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGATACGCTCAGCGATGAAGACAAACAGCTGTTTATCCGTCTGTTAGAAAACGACGATCCGGATC
TGTTTAACTGGCTGATGAATCATGGCGAACCGGCTGATGCGCAACTGCAACGGATGGTAAAATTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808XTM6

Antitoxin

Source ID Structure
AlphaFold DB A0A514ELX1

References