Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4762313..4762829 Replicon chromosome
Accession NZ_AP019665
Organism Klebsiella pneumoniae strain TA6363

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag TA6363_RS23310 Protein ID WP_009486548.1
Coordinates 4762313..4762597 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag TA6363_RS23315 Protein ID WP_002886901.1
Coordinates 4762587..4762829 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TA6363_RS23285 4757709..4758017 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
TA6363_RS23290 4758102..4758275 + 174 WP_004222159.1 hypothetical protein -
TA6363_RS23295 4758278..4759021 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
TA6363_RS23300 4759378..4761516 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
TA6363_RS23305 4761845..4762309 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
TA6363_RS23310 4762313..4762597 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TA6363_RS23315 4762587..4762829 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
TA6363_RS23320 4762907..4764817 - 1911 WP_004152270.1 BglG family transcription antiterminator -
TA6363_RS23325 4764840..4765994 - 1155 WP_004178372.1 lactonase family protein -
TA6363_RS23330 4766061..4766801 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T32836 WP_009486548.1 NZ_AP019665:c4762597-4762313 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T32836 NZ_AP019665:c4762597-4762313 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT32836 WP_002886901.1 NZ_AP019665:c4762829-4762587 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT32836 NZ_AP019665:c4762829-4762587 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References