Detailed information of TA system TA032818

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1247102..1247630
• Replicon: chromosome
• Accession: NZ_AP019657
• Organism: Vibrio ponticus strain DSM 16217

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GZN30_RS05480
• Protein ID: WP_075648887.1
• Coordinates: 1247102..1247392 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GZN30_RS05485
• Protein ID: WP_075648886.1
• Coordinates: 1247382..1247630 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GZN30_RS05470	1242882..1243553	+	672	WP_075648889.1	hypothetical protein	-
GZN30_RS05475	1243822..1246428	+	2607	WP_075648888.1	aminopeptidase N	-
GZN30_RS05480	1247102..1247392	-	291	WP_075648887.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GZN30_RS05485	1247382..1247630	-	249	WP_075648886.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GZN30_RS05490	1247996..1248535	+	540	WP_075648885.1	GNAT family N-acetyltransferase	-
GZN30_RS05495	1248851..1249162	+	312	WP_075651966.1	antibiotic biosynthesis monooxygenase	-
GZN30_RS05500	1249400..1250680	+	1281	WP_075651964.1	D-amino acid dehydrogenase	-
GZN30_RS05505	1250917..1251135	+	219	WP_075651961.1	DUF2835 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11328.37 Da
• Isoelectric Point: 10.7726

>T32818 WP_075648887.1 NZ_AP019657:c1247392-1247102 [Vibrio ponticus]
MTYKLNFKKTALKEWKKLGSTLQQQFKKKLIERLENPHVLASKLSGSDNMYKIKLRQSGYRLVYKVEDNVIIVTVLAIGK
RERNDVYRKAVKRLDD

Nucleotide

• Length: 291 bp

>T32818 NZ_AP019657:c1247392-1247102 [Vibrio ponticus]
ATGACTTATAAACTCAACTTTAAAAAGACCGCACTTAAAGAGTGGAAGAAGCTTGGCTCTACACTTCAACAACAATTTAA
GAAAAAGCTAATCGAACGCTTAGAAAACCCACATGTTTTGGCATCAAAACTCTCAGGTTCTGACAACATGTATAAAATTA
AGCTGCGTCAATCTGGCTATCGCCTAGTCTATAAAGTTGAAGATAATGTCATCATTGTAACAGTCCTGGCTATCGGCAAA
CGAGAACGCAATGATGTTTACCGTAAAGCTGTAAAAAGGCTAGATGACTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9070.34 Da
• Isoelectric Point: 4.0657

>AT32818 WP_075648886.1 NZ_AP019657:c1247630-1247382 [Vibrio ponticus]
MTTRILADVAASITELKANPMRVATSAEGKPVAVLNRNEPAFYCVPAETYEMMVDRLEDLELLAIAKERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT32818 NZ_AP019657:c1247630-1247382 [Vibrio ponticus]
ATGACCACTAGAATTTTGGCTGACGTTGCAGCAAGCATTACTGAACTAAAAGCTAACCCAATGAGAGTCGCGACTAGTGC
TGAGGGGAAACCAGTTGCCGTACTGAACCGAAACGAGCCGGCATTTTATTGCGTGCCTGCAGAAACATACGAAATGATGG
TGGATAGACTCGAAGATCTCGAACTACTAGCCATAGCTAAAGAACGAGAATCGGAAGAAAGCATATCTGTAAATATTGAT
GACTTATAA