Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3924472..3925271 Replicon chromosome
Accession NZ_AP019634
Organism Enterobacter sp. 18A13

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag FOY93_RS18910 Protein ID WP_123060711.1
Coordinates 3924894..3925271 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag FOY93_RS18905 Protein ID WP_123060710.1
Coordinates 3924472..3924837 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOY93_RS18860 3919877..3920284 + 408 WP_032233521.1 hypothetical protein -
FOY93_RS18865 3920356..3920583 + 228 WP_123060703.1 hypothetical protein -
FOY93_RS18870 3920886..3921722 + 837 WP_123060705.1 hypothetical protein -
FOY93_RS18875 3921816..3922049 + 234 WP_123060706.1 DUF905 domain-containing protein -
FOY93_RS18880 3922153..3922971 + 819 WP_143345534.1 DUF945 domain-containing protein -
FOY93_RS18885 3922971..3923225 + 255 WP_123060707.1 hypothetical protein -
FOY93_RS18890 3923313..3923723 + 411 Protein_3652 antirestriction protein -
FOY93_RS18895 3923735..3924199 + 465 WP_123060708.1 DNA repair protein RadC -
FOY93_RS18900 3924228..3924449 + 222 WP_123060709.1 DUF987 domain-containing protein -
FOY93_RS18905 3924472..3924837 + 366 WP_123060710.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FOY93_RS18910 3924894..3925271 + 378 WP_123060711.1 TA system toxin CbtA family protein Toxin
FOY93_RS18915 3925268..3925720 + 453 WP_143345536.1 hypothetical protein -
FOY93_RS18920 3925789..3925992 + 204 WP_123060713.1 DUF957 domain-containing protein -
FOY93_RS18925 3926074..3926916 + 843 WP_123060714.1 DUF4942 domain-containing protein -
FOY93_RS18930 3927191..3927583 - 393 WP_143345744.1 hypothetical protein -
FOY93_RS18935 3927876..3928403 - 528 WP_172621941.1 LuxR family transcriptional regulator -
FOY93_RS18940 3928682..3928930 + 249 WP_143345540.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3882431..3928930 46499


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13754.84 Da        Isoelectric Point: 9.9983

>T32814 WP_123060711.1 NZ_AP019634:3924894-3925271 [Enterobacter sp. 18A13]
MQTLSAIPARKAPSHPTPVEIWQRLLTYLLERHYGLSLNDTQFGNDGVIQQHIDAGLSLADALNFLVEKSELVRIDRPGF
SIQHQSPFISAIDILRARKAIGLMQRTGYKAVTCAISGRSSGGLK

Download         Length: 378 bp

>T32814 NZ_AP019634:3924894-3925271 [Enterobacter sp. 18A13]
ATGCAAACCTTATCCGCCATTCCGGCTCGGAAGGCACCATCACACCCAACGCCCGTTGAAATCTGGCAGCGACTTCTTAC
GTATCTGCTGGAAAGGCATTACGGCCTTTCGCTTAACGACACACAGTTTGGCAACGACGGTGTCATTCAGCAGCATATTG
ACGCCGGGCTTTCACTGGCAGATGCACTCAATTTTCTCGTTGAAAAATCTGAACTGGTACGAATTGATCGCCCCGGTTTC
TCCATTCAGCATCAGTCTCCGTTCATCAGCGCTATTGATATACTCCGGGCCAGAAAGGCCATCGGCCTGATGCAACGTAC
CGGTTATAAAGCGGTGACTTGCGCCATCAGTGGACGCTCTTCCGGAGGGCTGAAATGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13398.24 Da        Isoelectric Point: 5.9501

>AT32814 WP_123060710.1 NZ_AP019634:3924472-3924837 [Enterobacter sp. 18A13]
MPNTTPVANHDISEPWWGLKPTVTPCFGARLVQEGNHLHYLADRSTIEGTFSDADLRHLDQAFPVLMKQLELMLVSGELN
PRNQHCVTLYAKGLTLDADTLGSCGYLYIAIYPTSGNSIPR

Download         Length: 366 bp

>AT32814 NZ_AP019634:3924472-3924837 [Enterobacter sp. 18A13]
ATGCCGAACACAACACCTGTAGCAAACCATGATATTTCTGAGCCCTGGTGGGGACTTAAACCCACCGTCACGCCATGCTT
TGGCGCACGACTGGTACAGGAAGGCAACCACCTGCATTATCTGGCTGACCGCAGCACTATCGAAGGAACATTCAGCGACG
CGGATTTACGTCATCTCGACCAGGCCTTTCCGGTACTAATGAAGCAGCTTGAGTTAATGCTGGTTTCCGGTGAACTCAAT
CCCCGCAATCAGCATTGCGTCACGTTGTATGCAAAAGGTCTGACCCTCGACGCAGATACACTGGGCAGTTGTGGTTACCT
TTATATCGCGATTTATCCGACGTCAGGCAACAGCATCCCCCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References