Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3816300..3816957 Replicon chromosome
Accession NZ_AP019634
Organism Enterobacter sp. 18A13

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag FOY93_RS18305 Protein ID WP_021242050.1
Coordinates 3816300..3816710 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag FOY93_RS18310 Protein ID WP_006178375.1
Coordinates 3816691..3816957 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOY93_RS18285 3812293..3814026 - 1734 WP_133295108.1 single-stranded-DNA-specific exonuclease RecJ -
FOY93_RS18290 3814032..3814745 - 714 WP_029740340.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FOY93_RS18295 3814774..3815670 - 897 WP_133295109.1 site-specific tyrosine recombinase XerD -
FOY93_RS18300 3815772..3816293 + 522 WP_008499710.1 flavodoxin FldB -
FOY93_RS18305 3816300..3816710 - 411 WP_021242050.1 protein YgfX Toxin
FOY93_RS18310 3816691..3816957 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
FOY93_RS18315 3817252..3818232 + 981 WP_133295110.1 tRNA-modifying protein YgfZ -
FOY93_RS18320 3818343..3819002 - 660 WP_115876231.1 hemolysin III family protein -
FOY93_RS18325 3819168..3819479 - 312 WP_111963205.1 N(4)-acetylcytidine aminohydrolase -
FOY93_RS18330 3819531..3820262 + 732 WP_032660101.1 MurR/RpiR family transcriptional regulator -
FOY93_RS18335 3820379..3821812 + 1434 WP_115876233.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T32813 WP_021242050.1 NZ_AP019634:c3816710-3816300 [Enterobacter sp. 18A13]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T32813 NZ_AP019634:c3816710-3816300 [Enterobacter sp. 18A13]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGACTGGTTGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTAAGCTATACGCCGCTGTGGCTGCTGTTACTCTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGAATTAATGCCCGTCAGGGAGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATCCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTTTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGATCTGCGCCGGATGCTATTGCAACAGACGA
CGCAGGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT32813 WP_006178375.1 NZ_AP019634:c3816957-3816691 [Enterobacter sp. 18A13]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT32813 NZ_AP019634:c3816957-3816691 [Enterobacter sp. 18A13]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGAATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACACCTTAAGCGACGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCAGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGATACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References