Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3550337..3551021 Replicon chromosome
Accession NZ_AP019634
Organism Enterobacter sp. 18A13

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag FOY93_RS17085 Protein ID WP_143345427.1
Coordinates 3550692..3551021 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A9K1QZR3
Locus tag FOY93_RS17080 Protein ID WP_032642918.1
Coordinates 3550337..3550660 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOY93_RS17060 3547569..3548333 - 765 WP_063410037.1 hypothetical protein -
FOY93_RS17065 3548764..3549582 + 819 WP_172621920.1 DUF945 domain-containing protein -
FOY93_RS17070 3549615..3550085 + 471 WP_143345425.1 DNA repair protein RadC -
FOY93_RS17075 3550094..3550315 + 222 WP_143345426.1 DUF987 domain-containing protein -
FOY93_RS17080 3550337..3550660 + 324 WP_032642918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FOY93_RS17085 3550692..3551021 + 330 WP_143345427.1 TA system toxin CbtA family protein Toxin
FOY93_RS17090 3551363..3552409 - 1047 WP_143345737.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
FOY93_RS17095 3552393..3553169 - 777 WP_133294998.1 isocitrate lyase/phosphoenolpyruvate mutase family protein -
FOY93_RS17100 3553328..3553525 - 198 Protein_3307 nucleotidyltransferase domain-containing protein -
FOY93_RS17105 3553912..3554268 + 357 WP_008502540.1 hypothetical protein -
FOY93_RS17110 3554373..3554933 + 561 WP_133294999.1 YceI family protein -
FOY93_RS17115 3554925..3555716 - 792 WP_133295000.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3528592..3553558 24966


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(12-108)

Antitoxin

Antitoxin CbeA

(4-102)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12379.18 Da        Isoelectric Point: 5.5235

>T32811 WP_143345427.1 NZ_AP019634:3550692-3551021 [Enterobacter sp. 18A13]
MQISSVPVTVPVSSRLSPVMVWQQLLTYLLEHHYGLTLNDTPFHDDATIEEHIDAGITLADAVNFLVEKYELVRIDQKGF
SWQEQTPYISVVDILRARRSTGLLKANVK

Download         Length: 330 bp

>T32811 NZ_AP019634:3550692-3551021 [Enterobacter sp. 18A13]
ATGCAAATTTCATCTGTACCGGTCACGGTGCCGGTTTCGTCACGCCTGTCGCCCGTAATGGTGTGGCAGCAGCTTTTAAC
GTATCTGCTGGAGCACCATTACGGCCTGACACTTAATGACACGCCATTCCACGACGACGCGACTATTGAGGAACATATTG
ACGCGGGAATAACGCTTGCCGATGCGGTGAATTTTCTGGTGGAAAAGTACGAACTGGTTCGTATCGACCAGAAGGGATTT
TCGTGGCAAGAACAAACCCCGTATATTTCCGTAGTGGATATTCTGCGAGCAAGGCGATCTACCGGCTTGCTAAAAGCTAA
CGTGAAATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12082.82 Da        Isoelectric Point: 6.6250

>AT32811 WP_032642918.1 NZ_AP019634:3550337-3550660 [Enterobacter sp. 18A13]
MQNSWGLKRDISPCFGARLVQEGCRLHFLADRAGISGTFNEEEALRLDQAFPLVMKQLELMLTTGELNPRHQHCVTLYHN
GLTCEADTLGSHGYVYIVIYPQAFATR

Download         Length: 324 bp

>AT32811 NZ_AP019634:3550337-3550660 [Enterobacter sp. 18A13]
ATGCAAAATTCATGGGGACTGAAGCGCGACATCTCGCCGTGCTTCGGTGCAAGGCTTGTGCAGGAAGGCTGTCGCCTGCA
TTTTCTGGCGGACCGTGCAGGTATTAGTGGTACGTTTAACGAGGAGGAGGCACTGCGTCTGGATCAGGCATTTCCGCTAG
TGATGAAACAGCTTGAATTGATGCTGACAACCGGTGAACTGAATCCGCGCCATCAGCATTGCGTCACGTTGTATCATAAC
GGACTAACTTGTGAAGCTGACACTCTCGGCTCTCATGGCTATGTTTACATCGTTATTTATCCTCAGGCATTTGCAACCAG
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References