Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1118374..1118994 Replicon chromosome
Accession NZ_AP019634
Organism Enterobacter sp. 18A13

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag FOY93_RS05475 Protein ID WP_008499287.1
Coordinates 1118374..1118592 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag FOY93_RS05480 Protein ID WP_008499288.1
Coordinates 1118620..1118994 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOY93_RS05445 1114390..1114650 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
FOY93_RS05450 1114653..1114793 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
FOY93_RS05455 1114790..1115500 - 711 WP_133293898.1 GNAT family N-acetyltransferase -
FOY93_RS05460 1115601..1117061 + 1461 WP_143344767.1 PLP-dependent aminotransferase family protein -
FOY93_RS05465 1117033..1117500 - 468 WP_023310598.1 hypothetical protein -
FOY93_RS05470 1117618..1118169 - 552 WP_133293900.1 maltose O-acetyltransferase -
FOY93_RS05475 1118374..1118592 - 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
FOY93_RS05480 1118620..1118994 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
FOY93_RS05485 1119505..1122651 - 3147 WP_143344769.1 multidrug efflux RND transporter permease subunit AcrB -
FOY93_RS05490 1122674..1123867 - 1194 WP_045909753.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - acrB / acrA 1118374..1128300 9926


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T32802 WP_008499287.1 NZ_AP019634:c1118592-1118374 [Enterobacter sp. 18A13]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T32802 NZ_AP019634:c1118592-1118374 [Enterobacter sp. 18A13]
ATGTCTGATAAACCACTCACAAAGATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACGCTTGAACGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TAACAATGAATAAGCTGTATGACAAAATCCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT32802 WP_008499288.1 NZ_AP019634:c1118994-1118620 [Enterobacter sp. 18A13]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT32802 NZ_AP019634:c1118994-1118620 [Enterobacter sp. 18A13]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATCGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGTAGTTACGGCATTAACGCTCAGGATTTGCAAAAATGGCGTAAATCGGGAAATCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References