Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3927151..3927727 Replicon chromosome
Accession NZ_AP019632
Organism Enterobacter asburiae strain 1808-013

Toxin (Protein)


Gene name shpA Uniprot ID A0A4R0G892
Locus tag FOY96_RS18770 Protein ID WP_010427219.1
Coordinates 3927440..3927727 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A411GC49
Locus tag FOY96_RS18765 Protein ID WP_033144548.1
Coordinates 3927151..3927453 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOY96_RS18740 3923258..3923803 + 546 WP_143347567.1 porin -
FOY96_RS18745 3923803..3924123 + 321 WP_143347568.1 hypothetical protein -
FOY96_RS18750 3924169..3925539 - 1371 WP_143347569.1 NAD-dependent succinate-semialdehyde dehydrogenase -
FOY96_RS18755 3925691..3926434 + 744 WP_143347570.1 AraC family transcriptional regulator -
FOY96_RS18760 3926482..3927120 + 639 WP_143347571.1 LysE family translocator -
FOY96_RS18765 3927151..3927453 - 303 WP_033144548.1 BrnA antitoxin family protein Antitoxin
FOY96_RS18770 3927440..3927727 - 288 WP_010427219.1 BrnT family toxin Toxin
FOY96_RS18775 3927898..3929169 + 1272 WP_048980604.1 DUF445 domain-containing protein -
FOY96_RS18780 3929166..3930242 - 1077 WP_143347572.1 DUF2955 domain-containing protein -
FOY96_RS18785 3930232..3931299 - 1068 WP_143347573.1 HlyD family secretion protein -
FOY96_RS18790 3931296..3931766 - 471 WP_064673177.1 MarR family transcriptional regulator -
FOY96_RS18795 3931915..3932241 - 327 WP_143347574.1 winged helix-turn-helix domain-containing protein -
FOY96_RS18800 3932235..3932402 - 168 Protein_3640 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(32-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11174.64 Da        Isoelectric Point: 6.7609

>T32799 WP_010427219.1 NZ_AP019632:c3927727-3927440 [Enterobacter asburiae]
MPTEFEWDTNKAKSNLIKHGIRFEEAVLVFDDPYHLSLQDRHENGEFRWQTIGLVHGLIVIMVAHTVRFESGDEVIRIIS
ARKADRKERSRYEHG

Download         Length: 288 bp

>T32799 NZ_AP019632:c3927727-3927440 [Enterobacter asburiae]
ATGCCAACGGAGTTTGAATGGGATACCAACAAAGCGAAAAGCAATCTCATTAAGCATGGGATCCGCTTTGAAGAAGCTGT
TCTGGTGTTTGACGATCCTTACCATTTATCTTTGCAGGATCGTCATGAAAATGGAGAGTTCCGTTGGCAGACCATTGGCC
TTGTACATGGTCTAATTGTCATTATGGTCGCACACACGGTACGTTTTGAAAGTGGTGACGAAGTCATTCGAATCATTAGC
GCACGAAAGGCGGACCGTAAAGAGAGGAGCCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11395.04 Da        Isoelectric Point: 10.2483

>AT32799 WP_033144548.1 NZ_AP019632:c3927453-3927151 [Enterobacter asburiae]
MSMVKHKRGSAPEMSARREAELKALAEKSEAEIDYSDIPATGDEQWSGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp

>AT32799 NZ_AP019632:c3927453-3927151 [Enterobacter asburiae]
ATGAGCATGGTTAAACATAAACGCGGTAGTGCGCCTGAGATGAGTGCTCGCCGTGAGGCTGAGCTCAAAGCACTAGCCGA
AAAATCGGAAGCAGAGATTGATTACAGCGATATCCCTGCCACGGGAGATGAACAGTGGTCAGGGGCGGTGCGAGGGAAGT
TCTATCGGCCACTCAAAACTCAGGCGTCTGTACGTATCGACGCTGACGTGATGGAGTGGCTTAAACGGCCTGGAAAAGGT
TACCAGACGAGGCTCAATGCCATTTTGCGTGAAGCTATGCTGCGCGATCAAAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R0G892

Antitoxin

Source ID Structure
AlphaFold DB A0A411GC49

References