Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1627008..1627598 Replicon chromosome
Accession NZ_AP019632
Organism Enterobacter asburiae strain 1808-013

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag FOY96_RS07705 Protein ID WP_032658722.1
Coordinates 1627266..1627598 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag FOY96_RS07700 Protein ID WP_033145928.1
Coordinates 1627008..1627265 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOY96_RS07665 1622679..1623287 - 609 WP_143346794.1 glutathione S-transferase -
FOY96_RS07670 1623458..1624351 + 894 WP_143346795.1 LysR family transcriptional regulator -
FOY96_RS07675 1624529..1624882 + 354 WP_126795992.1 type II toxin-antitoxin system RelE/ParE family toxin -
FOY96_RS07680 1624887..1625189 + 303 WP_143346796.1 XRE family transcriptional regulator -
FOY96_RS07685 1625265..1626185 - 921 WP_143346797.1 LysR family transcriptional regulator -
FOY96_RS07690 1626327..1626716 + 390 WP_109845238.1 RidA family protein -
FOY96_RS07700 1627008..1627265 + 258 WP_033145928.1 antitoxin Antitoxin
FOY96_RS07705 1627266..1627598 + 333 WP_032658722.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FOY96_RS07715 1627893..1630082 - 2190 WP_045142987.1 TonB-dependent siderophore receptor -
FOY96_RS07720 1630109..1631434 - 1326 WP_143346798.1 SidA/IucD/PvdA family monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11814.63 Da        Isoelectric Point: 9.4051

>T32789 WP_032658722.1 NZ_AP019632:1627266-1627598 [Enterobacter asburiae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEGAGTTTTGVIRCDQPRTI
DMSARNGMRLERIPDAVVNEVLARLDAILN

Download         Length: 333 bp

>T32789 NZ_AP019632:1627266-1627598 [Enterobacter asburiae]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTTCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGTTACCGGTAGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACCGTTTCACTGGAAGGGGCGGGGACAACAACAACGGGCGTTATTCGCTGCGATCAGCCCAGAACCATT
GATATGTCTGCCCGGAACGGCATGCGGCTGGAACGCATACCTGACGCCGTTGTAAATGAAGTGCTTGCCAGGCTGGATGC
GATTCTGAATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9464.92 Da        Isoelectric Point: 4.4737

>AT32789 WP_033145928.1 NZ_AP019632:1627008-1627265 [Enterobacter asburiae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEEREWIDAPAV
GREIL

Download         Length: 258 bp

>AT32789 NZ_AP019632:1627008-1627265 [Enterobacter asburiae]
ATGTATACAACTCGTCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTCGGCATGACCATTAATAATGGCTGCCTGATTATTGAACCCCAGAAGCGGCCTCACTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCTGAAATGAGCGAAGAGGAGCGGGAATGGATCGATGCGCCTGCGGTG
GGCAGGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References