Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3847563..3848220 Replicon chromosome
Accession NZ_AP019630
Organism Enterobacter asburiae strain 17Nkhm-UP2

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag FOY94_RS18405 Protein ID WP_021242050.1
Coordinates 3847563..3847973 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag FOY94_RS18410 Protein ID WP_010435322.1
Coordinates 3847954..3848220 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOY94_RS18385 3843556..3845289 - 1734 WP_039262981.1 single-stranded-DNA-specific exonuclease RecJ -
FOY94_RS18390 3845295..3846008 - 714 WP_047060452.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FOY94_RS18395 3846037..3846933 - 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
FOY94_RS18400 3847035..3847556 + 522 WP_039262979.1 flavodoxin FldB -
FOY94_RS18405 3847563..3847973 - 411 WP_021242050.1 protein YgfX Toxin
FOY94_RS18410 3847954..3848220 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
FOY94_RS18415 3848515..3849495 + 981 WP_029739202.1 tRNA-modifying protein YgfZ -
FOY94_RS18420 3849570..3850229 - 660 WP_033146591.1 hemolysin III family protein -
FOY94_RS18425 3850395..3850706 - 312 WP_048980550.1 N(4)-acetylcytidine aminohydrolase -
FOY94_RS18430 3850758..3851489 + 732 WP_032660101.1 MurR/RpiR family transcriptional regulator -
FOY94_RS18435 3851606..3853039 + 1434 WP_048980547.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T32783 WP_021242050.1 NZ_AP019630:c3847973-3847563 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T32783 NZ_AP019630:c3847973-3847563 [Enterobacter asburiae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTTTTGCTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT32783 WP_010435322.1 NZ_AP019630:c3848220-3847954 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT32783 NZ_AP019630:c3848220-3847954 [Enterobacter asburiae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References