Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 1099250..1099752 Replicon chromosome
Accession NZ_AP019563
Organism Rickettsia asiatica strain Maytaro1284

Toxin (Protein)


Gene name relE Uniprot ID A0A510G8E8
Locus tag RAS_RS06545 Protein ID WP_010421450.1
Coordinates 1099250..1099504 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A510GDK8
Locus tag RAS_RS06550 Protein ID WP_010421447.1
Coordinates 1099504..1099752 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RAS_RS09085 1094775..1095281 - 507 Protein_1237 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
RAS_RS06520 1095373..1095749 - 377 Protein_1238 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
RAS_RS08780 1095752..1095922 - 171 WP_172616155.1 hypothetical protein -
RAS_RS06525 1095927..1096322 - 396 WP_147143373.1 Fic family protein -
RAS_RS06530 1096316..1096898 - 583 Protein_1241 virulence RhuM family protein -
RAS_RS06540 1097148..1099217 - 2070 WP_147143376.1 NAD-dependent DNA ligase LigA -
RAS_RS06545 1099250..1099504 - 255 WP_010421450.1 Txe/YoeB family addiction module toxin Toxin
RAS_RS06550 1099504..1099752 - 249 WP_010421447.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
RAS_RS06555 1099821..1100906 - 1086 WP_010421444.1 tRNA guanosine(34) transglycosylase Tgt -
RAS_RS06565 1101999..1102238 + 240 WP_147143379.1 hypothetical protein -
RAS_RS08785 1102368..1102673 + 306 Protein_1247 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -
RAS_RS08790 1102911..1103204 + 294 Protein_1248 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10140.75 Da        Isoelectric Point: 9.5156

>T32766 WP_010421450.1 NZ_AP019563:c1099504-1099250 [Rickettsia asiatica]
MEISFHIDAWADYLYFQKNDIKILEKINELIKDITRSPFTGIGKPEGLKYNLSGYWSRRINHEHRLIYTIKGKTVYILQC
KYHY

Download         Length: 255 bp

>T32766 NZ_AP019563:c1099504-1099250 [Rickettsia asiatica]
ATGGAAATATCATTTCACATTGATGCATGGGCAGATTATTTGTACTTTCAAAAAAATGATATAAAAATTCTAGAAAAAAT
AAATGAGCTAATTAAAGATATTACACGTTCTCCCTTTACGGGAATCGGTAAGCCTGAAGGCTTAAAGTACAATTTATCAG
GCTATTGGTCTCGCCGGATTAATCACGAACATAGGCTAATATATACTATTAAAGGTAAAACCGTTTATATATTACAATGT
AAATATCATTATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9500.97 Da        Isoelectric Point: 8.9405

>AT32766 WP_010421447.1 NZ_AP019563:c1099752-1099504 [Rickettsia asiatica]
MEAISYTKARNNFADIMERVCADHTSVVVTRQKQKPVVIMSLEDYNAMEETLYLLKSPKNAERLKRAINDFEANKNFKTM
SL

Download         Length: 249 bp

>AT32766 NZ_AP019563:c1099752-1099504 [Rickettsia asiatica]
ATGGAAGCAATATCTTACACTAAAGCAAGAAATAATTTTGCAGATATTATGGAAAGAGTTTGTGCAGATCACACTTCAGT
GGTTGTAACTAGACAAAAACAAAAACCGGTGGTTATTATGTCTCTTGAAGACTATAATGCTATGGAGGAAACTTTATATT
TATTAAAAAGCCCTAAAAATGCTGAAAGACTAAAACGAGCAATTAATGATTTTGAAGCAAATAAAAACTTTAAAACAATG
TCTTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510G8E8

Antitoxin

Source ID Structure
AlphaFold DB A0A510GDK8

References