Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 630476..631035 Replicon chromosome
Accession NZ_AP019563
Organism Rickettsia asiatica strain Maytaro1284

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag RAS_RS03620 Protein ID WP_147142426.1
Coordinates 630706..631035 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag RAS_RS03615 Protein ID WP_147142423.1
Coordinates 630476..630712 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RAS_RS03590 626394..626642 - 249 WP_010423207.1 DUF3035 domain-containing protein -
RAS_RS03595 626663..627253 - 591 WP_147142416.1 lipoprotein signal peptidase -
RAS_RS03600 627415..628779 - 1365 WP_147142419.1 peptidoglycan DD-metalloendopeptidase family protein -
RAS_RS03605 628965..629521 + 557 Protein_688 FAD synthase -
RAS_RS03610 629595..630404 + 810 WP_147142422.1 cytochrome c oxidase subunit II -
RAS_RS03615 630476..630712 + 237 WP_147142423.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
RAS_RS03620 630706..631035 + 330 WP_147142426.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
RAS_RS03625 631048..631666 + 619 Protein_692 CatB-related O-acetyltransferase -
RAS_RS03630 631672..633270 + 1599 WP_147142429.1 cytochrome c oxidase subunit I -
RAS_RS03635 633371..633442 + 72 WP_083831857.1 palindromic element RPE4 domain-containing protein -
RAS_RS03640 633493..634221 + 729 WP_147142432.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
RAS_RS03645 634307..634627 - 321 WP_147142437.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-107)

Antitoxin

Antitoxin PemI-like

(1-78)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12439.72 Da        Isoelectric Point: 9.8553

>T32765 WP_147142426.1 NZ_AP019563:630706-631035 [Rickettsia asiatica]
MVAYIPERGDVVWLDFDPQKGNEIKKIRPAIVLSTYKYHLKSNLALFVPITSQIKGYPFEVIINIDSINGAVLCDQIRSM
DFKARKAKKILSLNNSLVDEILYKSKLLL

Download         Length: 330 bp

>T32765 NZ_AP019563:630706-631035 [Rickettsia asiatica]
ATGGTAGCTTATATACCTGAAAGAGGTGATGTAGTTTGGCTTGATTTTGATCCTCAAAAAGGTAATGAAATTAAAAAAAT
ACGACCGGCTATTGTGCTTAGCACCTACAAATACCACCTTAAAAGTAATCTTGCTTTATTTGTCCCTATTACTAGTCAGA
TTAAAGGTTACCCATTTGAAGTAATAATAAATATAGATTCTATAAATGGTGCAGTATTGTGTGATCAAATTAGATCTATG
GATTTTAAAGCACGTAAAGCAAAAAAAATTCTAAGCTTAAATAATTCACTTGTAGATGAAATACTATATAAATCAAAACT
ATTACTTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8802.88 Da        Isoelectric Point: 4.6805

>AT32765 WP_147142423.1 NZ_AP019563:630476-630712 [Rickettsia asiatica]
MKAQIQQWGNSLGVRIPQVLARKLHFKQGIVVNLEITDDGLFISAKTSELDILLDDITDANRHHEVFNSDDTVGNESW

Download         Length: 237 bp

>AT32765 NZ_AP019563:630476-630712 [Rickettsia asiatica]
ATGAAAGCTCAAATTCAACAATGGGGAAATAGTTTAGGAGTTAGAATTCCTCAAGTTTTAGCTAGAAAACTACATTTTAA
GCAAGGAATAGTTGTTAATCTAGAAATAACTGATGATGGTTTGTTTATTAGTGCTAAAACCTCTGAATTAGATATTTTAC
TAGATGATATTACTGATGCTAATCGTCATCATGAGGTATTTAATAGCGATGATACGGTAGGTAATGAGTCATGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References