Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 1606193..1606695 Replicon chromosome
Accession NZ_AP019547
Organism Candidatus Nitrotoga sp. AM1P

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag W01_RS07135 Protein ID WP_173053352.1
Coordinates 1606441..1606695 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag W01_RS07130 Protein ID WP_173053350.1
Coordinates 1606193..1606444 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
W01_RS07095 1601975..1602505 + 531 WP_173053338.1 D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase -
W01_RS07100 1602579..1603283 + 705 WP_173053340.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
W01_RS07105 1603283..1604026 + 744 WP_173053342.1 M48 family metallopeptidase -
W01_RS07110 1604227..1604522 + 296 Protein_1396 DNA-binding protein -
W01_RS07115 1604613..1604771 - 159 WP_173053344.1 hypothetical protein -
W01_RS07120 1604913..1605194 + 282 WP_173053346.1 DUF768 domain-containing protein -
W01_RS07125 1605642..1606079 + 438 WP_173053348.1 DUF3592 domain-containing protein -
W01_RS07130 1606193..1606444 + 252 WP_173053350.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
W01_RS07135 1606441..1606695 + 255 WP_173053352.1 Txe/YoeB family addiction module toxin Toxin
W01_RS07140 1606852..1607076 + 225 WP_173053354.1 hypothetical protein -
W01_RS07145 1607296..1607859 + 564 WP_173053356.1 hypothetical protein -
W01_RS07150 1608050..1608592 + 543 WP_173053358.1 transposase -
W01_RS07155 1608875..1610122 + 1248 WP_173053360.1 diaminopimelate decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10204.77 Da        Isoelectric Point: 8.4983

>T32763 WP_173053352.1 NZ_AP019547:1606441-1606695 [Candidatus Nitrotoga sp. AM1P]
VRLIFADDAWEDYLYWQKQDKRMIERINKLIRETQREPFAGIGKPEQLKHALSGFWSRRITDEHRMVYCIESGACMIAQL
RFHY

Download         Length: 255 bp

>T32763 NZ_AP019547:1606441-1606695 [Candidatus Nitrotoga sp. AM1P]
GTGAGGCTGATCTTCGCTGATGATGCATGGGAAGACTATCTATATTGGCAGAAGCAAGACAAGCGCATGATCGAGCGAAT
TAACAAGCTGATACGTGAGACACAGCGGGAGCCCTTCGCGGGAATAGGCAAACCCGAACAATTGAAGCATGCCCTTTCAG
GGTTCTGGTCACGCCGAATTACGGATGAGCATCGCATGGTGTATTGCATAGAGAGTGGTGCATGTATGATCGCTCAGTTG
CGTTTCCACTACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9290.70 Da        Isoelectric Point: 5.8208

>AT32763 WP_173053350.1 NZ_AP019547:1606193-1606444 [Candidatus Nitrotoga sp. AM1P]
MDAITYTTVRANLASAMDRVCDDHEPLIITRNGEQSVVMLSLEDYKSLEETAYLLRTPANARRLLAAIVQLNEGKGVERK
LVK

Download         Length: 252 bp

>AT32763 NZ_AP019547:1606193-1606444 [Candidatus Nitrotoga sp. AM1P]
ATGGATGCGATTACCTATACCACCGTTCGTGCAAATCTCGCGAGTGCCATGGACCGCGTTTGCGACGATCACGAACCCTT
GATCATTACCCGCAATGGAGAACAATCCGTCGTGATGCTCTCACTCGAAGACTACAAATCGCTGGAAGAAACTGCCTACC
TCTTGCGCACCCCCGCCAATGCCAGGCGCCTTCTCGCTGCCATCGTGCAATTGAATGAAGGTAAAGGCGTTGAACGGAAG
TTGGTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References