Detailed information of TA system TA032760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 648612..649282
• Replicon: chromosome
• Accession: NZ_AP019547
• Organism: Candidatus Nitrotoga sp. AM1P

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: W01_RS02970
• Protein ID: WP_173052129.1
• Coordinates: 648860..649282 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: W01_RS02965
• Protein ID: WP_173052128.1
• Coordinates: 648612..648863 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
W01_RS02945	644953..645267	-	315	WP_173052124.1	hypothetical protein	-
W01_RS02950	645276..645875	-	600	WP_173052125.1	hypothetical protein	-
W01_RS02955	646410..647801	+	1392	WP_173052126.1	IS4 family transposase	-
W01_RS02960	647982..648281	-	300	WP_173052127.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
W01_RS02965	648612..648863	+	252	WP_173052128.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
W01_RS02970	648860..649282	+	423	WP_173052129.1	type II toxin-antitoxin system VapC family toxin	Toxin
W01_RS13845	649464..649640	-	177	WP_198421330.1	hypothetical protein	-
W01_RS02980	649814..650173	-	360	WP_173052130.1	DUF2513 domain-containing protein	-
W01_RS13850	650277..650942	-	666	WP_198421331.1	HNH endonuclease	-
W01_RS02990	651316..651726	-	411	WP_198421332.1	hypothetical protein	-
W01_RS02995	651738..653045	-	1308	WP_173052131.1	hypothetical protein	-
W01_RS03000	653172..654260	-	1089	WP_173052132.1	carotenoid 1,2-hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-71)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15632.12 Da
• Isoelectric Point: 6.0719

>T32760 WP_173052129.1 NZ_AP019547:648860-649282 [Candidatus Nitrotoga sp. AM1P]
MSWLLDTCALSEYAKKAPAPKVIAWLDEQDESSLFISVITLGEIEKDILKLRASDPHRSQKLTDWLGKVEQRFAGRILPL
NAAALHVWAQITAHSELAGQPMPVMDGLLMATAQCHGFTVVTRNVQDFAMYPQVFNPWAL

Nucleotide

• Length: 423 bp

>T32760 NZ_AP019547:648860-649282 [Candidatus Nitrotoga sp. AM1P]
ATGAGCTGGCTGCTGGATACCTGCGCGCTTTCCGAATACGCCAAAAAAGCCCCTGCCCCGAAAGTTATCGCCTGGCTAGA
TGAACAAGACGAATCCAGCCTGTTCATCAGTGTCATCACGCTGGGAGAAATCGAAAAAGACATCCTCAAACTGCGCGCAA
GCGACCCGCACCGCAGCCAGAAACTCACTGATTGGCTGGGTAAAGTAGAGCAGCGCTTCGCTGGGCGCATCCTGCCGCTC
AATGCCGCTGCCCTTCACGTCTGGGCGCAAATCACCGCACACTCCGAACTGGCTGGACAACCCATGCCGGTGATGGACGG
CCTGCTCATGGCCACTGCCCAATGCCACGGTTTCACTGTGGTTACCCGTAACGTGCAGGATTTCGCGATGTACCCGCAAG
TGTTTAATCCTTGGGCGTTGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9284.48 Da
• Isoelectric Point: 8.6983

>AT32760 WP_173052128.1 NZ_AP019547:648612-648863 [Candidatus Nitrotoga sp. AM1P]
MHREWQLQKAKDNFSQLIKGAASGDTQVVTVHGKPTAVIVSAEEYARLTRHRTKLSSVLLRPDLAAEDLDISRSRDTGRD
IDL

Nucleotide

• Length: 252 bp

>AT32760 NZ_AP019547:648612-648863 [Candidatus Nitrotoga sp. AM1P]
ATGCACAGAGAATGGCAACTACAAAAAGCAAAAGACAATTTCAGCCAGCTTATCAAGGGGGCCGCGAGTGGCGATACTCA
AGTAGTTACGGTGCACGGAAAACCCACAGCGGTAATTGTTTCGGCTGAAGAATATGCCCGGCTCACCCGCCACCGAACCA
AGCTCTCCAGCGTGCTGCTGCGTCCCGACCTCGCAGCCGAAGATCTGGATATTTCCCGCAGCCGCGACACCGGGCGCGAC
ATTGATCTATGA