Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 174929..175406 Replicon chromosome
Accession NZ_AP019547
Organism Candidatus Nitrotoga sp. AM1P

Toxin (Protein)


Gene name pasB Uniprot ID -
Locus tag W01_RS00810 Protein ID WP_173051771.1
Coordinates 174929..175195 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag W01_RS00815 Protein ID WP_173051772.1
Coordinates 175179..175406 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
W01_RS00785 169979..170182 + 204 WP_173051768.1 hypothetical protein -
W01_RS00790 170251..170820 + 570 WP_173051769.1 redoxin domain-containing protein -
W01_RS00795 170970..172142 - 1173 WP_173055623.1 GIY-YIG nuclease family protein -
W01_RS00800 172168..174285 - 2118 WP_173051770.1 DEAD/DEAH box helicase -
W01_RS00805 174732..174920 - 189 WP_173051636.1 hypothetical protein -
W01_RS00810 174929..175195 - 267 WP_173051771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
W01_RS00815 175179..175406 - 228 WP_173051772.1 CopG family transcriptional regulator Antitoxin
W01_RS00820 175494..178280 - 2787 WP_173051773.1 class I SAM-dependent DNA methyltransferase -
W01_RS13800 178414..178593 + 180 WP_198421311.1 hypothetical protein -
W01_RS00830 178712..179041 - 330 WP_173051774.1 HigA family addiction module antidote protein -
W01_RS00835 179053..179331 - 279 WP_173051775.1 type II toxin-antitoxin system RelE/ParE family toxin -
W01_RS13805 179608..179784 - 177 WP_198421312.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10130.63 Da        Isoelectric Point: 10.0481

>T32758 WP_173051771.1 NZ_AP019547:c175195-174929 [Candidatus Nitrotoga sp. AM1P]
MAWTIDYAETAKGQLRKLDKQTARRIVDFMDERVAGRENPRDSGKALTGSLGGFWRYRVGDCRVICDIQDGVLRVLVVQI
GNRREIYR

Download         Length: 267 bp

>T32758 NZ_AP019547:c175195-174929 [Candidatus Nitrotoga sp. AM1P]
TTGGCCTGGACAATTGATTATGCGGAGACAGCCAAAGGGCAGCTACGCAAGCTGGACAAGCAGACGGCGCGTCGCATCGT
TGATTTTATGGATGAGCGGGTCGCCGGACGGGAAAATCCGCGCGACTCAGGCAAAGCGCTGACCGGCTCGCTGGGTGGTT
TCTGGCGTTATCGCGTGGGCGACTGCCGGGTGATTTGCGACATTCAGGACGGTGTATTGCGCGTGCTCGTGGTGCAGATT
GGCAACCGGCGCGAAATTTACCGATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8681.76 Da        Isoelectric Point: 4.8430

>AT32758 WP_173051772.1 NZ_AP019547:c175406-175179 [Candidatus Nitrotoga sp. AM1P]
MATSIRLAPEIEQRLDYLASHTGRTKAYYLREIIERGIEEMEDYYLAADVLERVRKGQEQVHSAADVRKDLGLDN

Download         Length: 228 bp

>AT32758 NZ_AP019547:c175406-175179 [Candidatus Nitrotoga sp. AM1P]
ATGGCAACTTCGATTCGCCTTGCTCCTGAAATCGAGCAAAGGCTTGATTACCTTGCCTCCCATACCGGGCGCACCAAGGC
GTACTACCTGCGCGAAATCATCGAGCGGGGCATCGAGGAAATGGAGGACTATTATCTTGCCGCCGACGTGCTGGAGCGTG
TCCGCAAGGGACAAGAACAGGTGCATTCCGCTGCTGACGTGAGAAAAGACCTTGGCCTGGACAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References