Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 59744..60279 Replicon chromosome
Accession NZ_AP019547
Organism Candidatus Nitrotoga sp. AM1P

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag W01_RS00285 Protein ID WP_173051691.1
Coordinates 60004..60279 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag W01_RS00280 Protein ID WP_173051690.1
Coordinates 59744..60004 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
W01_RS00240 54815..55852 + 1038 WP_173051683.1 23S rRNA (cytidine(2498)-2'-O)-methyltransferase RlmM -
W01_RS00245 55913..56233 - 321 WP_173051684.1 cytochrome C -
W01_RS00250 56490..56978 - 489 WP_173051685.1 GNAT family N-acetyltransferase -
W01_RS00255 57136..57303 + 168 WP_173051686.1 hypothetical protein -
W01_RS13785 57580..58092 + 513 WP_198421305.1 IS630 family transposase -
W01_RS00265 58360..58641 - 282 WP_173051687.1 hypothetical protein -
W01_RS00270 58985..59491 - 507 WP_173051688.1 YifB family Mg chelatase-like AAA ATPase -
W01_RS00275 59493..59720 + 228 WP_173051689.1 helix-turn-helix domain-containing protein -
W01_RS00280 59744..60004 + 261 WP_173051690.1 ribbon-helix-helix domain-containing protein Antitoxin
W01_RS00285 60004..60279 + 276 WP_173051691.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
W01_RS00290 60512..61762 - 1251 WP_173051692.1 DDE-type integrase/transposase/recombinase -
W01_RS00295 62002..62431 - 430 Protein_55 IS200/IS605 family transposase -
W01_RS00300 63547..64677 - 1131 WP_173051693.1 redoxin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10763.63 Da        Isoelectric Point: 10.4492

>T32757 WP_173051691.1 NZ_AP019547:60004-60279 [Candidatus Nitrotoga sp. AM1P]
MKLKWTSKGLSDLVRLYEFLSPLNKKTAIATVQVLTAAPAKLLAQPRIGEKLEEFEPREIRRILVGHYEIRYEIQQSTIY
VLRLWHTRENR

Download         Length: 276 bp

>T32757 NZ_AP019547:60004-60279 [Candidatus Nitrotoga sp. AM1P]
ATGAAATTGAAATGGACGAGCAAGGGATTGTCCGATTTAGTCAGGTTGTATGAGTTTCTCTCGCCGCTGAATAAAAAAAC
CGCAATAGCTACGGTACAAGTATTGACAGCAGCTCCTGCAAAACTTCTGGCACAGCCTCGTATTGGAGAAAAGCTGGAAG
AGTTTGAGCCGCGTGAAATACGTCGCATTTTGGTGGGACATTATGAAATACGTTACGAAATTCAACAGTCCACTATTTAT
GTACTACGACTCTGGCACACACGAGAGAATCGCTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9811.21 Da        Isoelectric Point: 5.0893

>AT32757 WP_173051690.1 NZ_AP019547:59744-60004 [Candidatus Nitrotoga sp. AM1P]
MNTKVLTAHVPIPLAEKVDQIAARMERSRGWVMKQALSAWVDQEEERRRLTLESMADIETGQVIDHQFVQAWAESLSTDT
PLPVPR

Download         Length: 261 bp

>AT32757 NZ_AP019547:59744-60004 [Candidatus Nitrotoga sp. AM1P]
ATGAATACAAAAGTGCTAACTGCGCATGTCCCGATACCTCTTGCCGAGAAAGTTGATCAAATCGCTGCTCGCATGGAGCG
TTCGCGTGGCTGGGTTATGAAGCAAGCATTGTCCGCTTGGGTAGATCAAGAAGAAGAGCGTCGGCGATTGACCTTGGAAT
CGATGGCTGACATTGAAACAGGGCAGGTTATCGACCATCAGTTTGTTCAAGCTTGGGCTGAAAGCCTGAGTACCGACACT
CCTTTGCCGGTACCGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References