32736

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 881833..882310 Replicon chromosome
Accession NZ_AP019545
Organism Staphylococcus aureus strain KG-22

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag GDK20_RS04295 Protein ID WP_000052076.1
Coordinates 881833..882021 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag GDK20_RS04300 Protein ID WP_001059690.1
Coordinates 882050..882310 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GDK20_RS04265 877827..878348 + 522 WP_000824482.1 hypothetical protein -
GDK20_RS04270 878689..879375 + 687 WP_000141557.1 thermonuclease family protein -
GDK20_RS04275 879732..879932 + 201 WP_001059082.1 cold-shock protein -
GDK20_RS04280 880424..880642 - 219 WP_000005886.1 hypothetical protein -
GDK20_RS04285 880704..880988 - 285 WP_001004399.1 hypothetical protein -
GDK20_RS04290 881076..881645 - 570 WP_001106654.1 hypothetical protein -
GDK20_RS04295 881833..882021 - 189 WP_000052076.1 hypothetical protein Toxin
GDK20_RS04300 882050..882310 - 261 WP_001059690.1 hypothetical protein Antitoxin
GDK20_RS04305 882651..882854 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
GDK20_RS04310 882851..883087 - 237 WP_000349581.1 hypothetical protein -
GDK20_RS04315 883312..883893 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
GDK20_RS04320 883966..884583 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
GDK20_RS04325 884738..885232 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
GDK20_RS04330 885631..886053 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
GDK20_RS04335 886201..886917 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 847972..892852 44880


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T32736 WP_000052076.1 NZ_AP019545:c882021-881833 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T32736 NZ_AP019545:c882021-881833 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT32736 WP_001059690.1 NZ_AP019545:c882310-882050 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT32736 NZ_AP019545:c882310-882050 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References