Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2249094..2249608 Replicon chromosome
Accession NZ_AP019543
Organism Staphylococcus aureus strain KG-18

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag GDK18_RS11435 Protein ID WP_000581792.1
Coordinates 2249094..2249303 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag GDK18_RS11440 Protein ID WP_000138932.1
Coordinates 2249315..2249608 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GDK18_RS11415 2244602..2245960 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
GDK18_RS11420 2245975..2247045 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
GDK18_RS11425 2247363..2248565 + 1203 WP_001109939.1 rod shape-determining protein RodA -
GDK18_RS11430 2248829..2248966 - 138 WP_000828354.1 hypothetical protein -
GDK18_RS11435 2249094..2249303 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
GDK18_RS11440 2249315..2249608 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
GDK18_RS11445 2249774..2251258 + 1485 WP_000571549.1 cardiolipin synthase -
GDK18_RS11450 2251286..2251933 + 648 WP_001187630.1 HD domain-containing protein -
GDK18_RS11475 2252846..2253718 - 873 WP_000725802.1 membrane protein insertase YidC -
GDK18_RS11480 2253804..2254445 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T32726 WP_000581792.1 NZ_AP019543:c2249303-2249094 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T32726 NZ_AP019543:c2249303-2249094 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT32726 WP_000138932.1 NZ_AP019543:c2249608-2249315 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT32726 NZ_AP019543:c2249608-2249315 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References