Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TscAT/- |
Location | 855516..856045 | Replicon | chromosome |
Accession | NZ_AP019543 | ||
Organism | Staphylococcus aureus strain KG-18 |
Toxin (Protein)
Gene name | TscT | Uniprot ID | K7ZRX2 |
Locus tag | GDK18_RS04120 | Protein ID | WP_001103933.1 |
Coordinates | 855728..856045 (+) | Length | 106 a.a. |
Antitoxin (Protein)
Gene name | TscA | Uniprot ID | A0A6B0BJC0 |
Locus tag | GDK18_RS04115 | Protein ID | WP_001058487.1 |
Coordinates | 855516..855725 (+) | Length | 70 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GDK18_RS04080 | 851967..852431 | + | 465 | WP_001085183.1 | SsrA-binding protein SmpB | - |
GDK18_RS04090 | 852994..854100 | - | 1107 | WP_000121223.1 | site-specific integrase | - |
GDK18_RS04095 | 854106..854753 | - | 648 | WP_072474260.1 | helix-turn-helix domain-containing protein | - |
GDK18_RS04100 | 854911..855117 | + | 207 | WP_001060953.1 | hypothetical protein | - |
GDK18_RS04105 | 855153..855380 | + | 228 | WP_000164237.1 | helix-turn-helix domain-containing protein | - |
GDK18_RS04110 | 855377..855523 | + | 147 | WP_000784893.1 | hypothetical protein | - |
GDK18_RS04115 | 855516..855725 | + | 210 | WP_001058487.1 | hypothetical protein | Antitoxin |
GDK18_RS04120 | 855728..856045 | + | 318 | WP_001103933.1 | DUF1474 family protein | Toxin |
GDK18_RS04125 | 856112..856981 | + | 870 | WP_001002695.1 | primase alpha helix C-terminal domain-containing protein | - |
GDK18_RS04130 | 856998..858467 | + | 1470 | WP_001668899.1 | virulence-associated E family protein | - |
GDK18_RS04140 | 858753..859115 | + | 363 | WP_001039169.1 | hypothetical protein | - |
GDK18_RS04145 | 859117..859401 | + | 285 | WP_000998179.1 | hypothetical protein | - |
GDK18_RS04150 | 859398..860039 | + | 642 | WP_001019810.1 | hypothetical protein | - |
GDK18_RS04155 | 860489..860830 | + | 342 | WP_001190615.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | vWbp | 849573..890111 | 40538 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12511.13 Da Isoelectric Point: 4.6364
>T32713 WP_001103933.1 NZ_AP019543:855728-856045 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE
Download Length: 318 bp
>T32713 NZ_AP019543:855728-856045 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTAA
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTAA
Antitoxin
Download Length: 70 a.a. Molecular weight: 8228.24 Da Isoelectric Point: 4.1682
>AT32713 WP_001058487.1 NZ_AP019543:855516-855725 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE
Download Length: 210 bp
>AT32713 NZ_AP019543:855516-855725 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCCTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCCTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | K7ZRX2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6B0BJC0 |