Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 855516..856045 Replicon chromosome
Accession NZ_AP019543
Organism Staphylococcus aureus strain KG-18

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag GDK18_RS04120 Protein ID WP_001103933.1
Coordinates 855728..856045 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag GDK18_RS04115 Protein ID WP_001058487.1
Coordinates 855516..855725 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GDK18_RS04080 851967..852431 + 465 WP_001085183.1 SsrA-binding protein SmpB -
GDK18_RS04090 852994..854100 - 1107 WP_000121223.1 site-specific integrase -
GDK18_RS04095 854106..854753 - 648 WP_072474260.1 helix-turn-helix domain-containing protein -
GDK18_RS04100 854911..855117 + 207 WP_001060953.1 hypothetical protein -
GDK18_RS04105 855153..855380 + 228 WP_000164237.1 helix-turn-helix domain-containing protein -
GDK18_RS04110 855377..855523 + 147 WP_000784893.1 hypothetical protein -
GDK18_RS04115 855516..855725 + 210 WP_001058487.1 hypothetical protein Antitoxin
GDK18_RS04120 855728..856045 + 318 WP_001103933.1 DUF1474 family protein Toxin
GDK18_RS04125 856112..856981 + 870 WP_001002695.1 primase alpha helix C-terminal domain-containing protein -
GDK18_RS04130 856998..858467 + 1470 WP_001668899.1 virulence-associated E family protein -
GDK18_RS04140 858753..859115 + 363 WP_001039169.1 hypothetical protein -
GDK18_RS04145 859117..859401 + 285 WP_000998179.1 hypothetical protein -
GDK18_RS04150 859398..860039 + 642 WP_001019810.1 hypothetical protein -
GDK18_RS04155 860489..860830 + 342 WP_001190615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 849573..890111 40538


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T32713 WP_001103933.1 NZ_AP019543:855728-856045 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T32713 NZ_AP019543:855728-856045 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT32713 WP_001058487.1 NZ_AP019543:855516-855725 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT32713 NZ_AP019543:855516-855725 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCCTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References