Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2434099..2434844 Replicon chromosome
Accession NZ_AP019531
Organism Serratia symbiotica strain IS

Toxin (Protein)


Gene name tacT Uniprot ID A0A068RBN2
Locus tag SSYIS1_RS12370 Protein ID WP_061770371.1
Coordinates 2434353..2434844 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID E9CQZ6
Locus tag SSYIS1_RS12365 Protein ID WP_006710107.1
Coordinates 2434099..2434365 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSYIS1_RS12345 2429280..2429750 + 471 WP_006708289.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
SSYIS1_RS12350 2429786..2431681 + 1896 WP_006708290.1 peptidoglycan DD-transpeptidase MrdA -
SSYIS1_RS12355 2431693..2432805 + 1113 WP_006708291.1 peptidoglycan glycosyltransferase MrdB -
SSYIS1_RS12360 2432816..2433816 + 1001 Protein_2367 endolytic peptidoglycan transglycosylase RlpA -
SSYIS1_RS12365 2434099..2434365 + 267 WP_006710107.1 DUF1778 domain-containing protein Antitoxin
SSYIS1_RS12370 2434353..2434844 + 492 WP_061770371.1 GNAT family N-acetyltransferase Toxin
SSYIS1_RS12375 2435075..2436286 + 1212 WP_006708292.1 D-alanyl-D-alanine carboxypeptidase DacA -
SSYIS1_RS12380 2436736..2437360 + 625 Protein_2371 IS1 family transposase -
SSYIS1_RS12385 2437972..2438238 + 267 WP_006708294.1 DUF493 family protein YbeD -
SSYIS1_RS12390 2438371..2439039 + 669 WP_037388216.1 lipoyl(octanoyl) transferase LipB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2283731..2486747 203016


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-148)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17861.71 Da        Isoelectric Point: 9.9670

>T32661 WP_061770371.1 NZ_AP019531:2434353-2434844 [Serratia symbiotica]
VGKVTAPTPLNTTHILSEFHSRETALDEWIKHQGLKNQSIGAARTFVVCREHSSQVVGFYSLATGSVTHVIAPRSLRRNM
PDPIPVIILARLAVDAGYHGKGLSADLLHDAVLRICRVAENIGVRAIMVHALSDAAKQFYLHHGLMQSTTQEKTLFLRLP
GIV

Download         Length: 492 bp

>T32661 NZ_AP019531:2434353-2434844 [Serratia symbiotica]
GTGGGAAAAGTAACAGCACCGACACCGCTCAACACGACACACATTCTTTCAGAGTTCCACTCCAGGGAAACAGCACTGGA
TGAATGGATCAAACACCAGGGATTGAAAAATCAATCCATCGGTGCAGCAAGGACGTTTGTGGTATGCAGGGAACATTCTT
CACAGGTGGTCGGTTTTTACTCACTGGCTACTGGTAGTGTGACTCATGTTATTGCACCAAGAAGCCTTCGACGAAACATG
CCTGATCCCATCCCGGTCATAATACTGGCAAGACTCGCTGTCGATGCGGGTTACCATGGTAAGGGCCTTAGCGCTGATTT
ACTTCACGATGCAGTATTACGCATCTGTCGCGTGGCAGAAAATATCGGGGTACGGGCCATCATGGTTCATGCCCTGTCTG
ACGCGGCAAAACAATTTTATCTGCATCATGGGCTTATGCAGTCAACCACTCAAGAAAAAACGCTTTTTCTCCGATTGCCT
GGTATTGTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10055.54 Da        Isoelectric Point: 4.6027

>AT32661 WP_006710107.1 NZ_AP019531:2434099-2434365 [Serratia symbiotica]
MKSDVQLNIRAKEAQRVLIDTAADILHKSRTDFILEIACQAAENVLLDRRMFNLNDEQYAEFIDMLDAPVTANPALDALL
ARKPQWEK

Download         Length: 267 bp

>AT32661 NZ_AP019531:2434099-2434365 [Serratia symbiotica]
ATGAAATCTGATGTTCAGCTCAATATTCGGGCAAAAGAGGCTCAGCGAGTACTGATCGATACAGCAGCCGACATTCTACA
TAAATCGCGTACTGACTTTATCCTCGAGATAGCCTGTCAGGCTGCTGAAAACGTGCTTCTTGATCGCCGGATGTTTAATC
TCAATGATGAACAATACGCAGAATTTATCGATATGCTGGATGCACCAGTCACAGCGAATCCGGCACTGGATGCACTCCTG
GCGAGAAAACCGCAGTGGGAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068RBN2

Antitoxin

Source ID Structure
AlphaFold DB A0A068RB60

References