Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1965436..1966105 Replicon chromosome
Accession NZ_AP019531
Organism Serratia symbiotica strain IS

Toxin (Protein)


Gene name cptA Uniprot ID E9CNM4
Locus tag SSYIS1_RS10010 Protein ID WP_006709291.1
Coordinates 1965683..1966105 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID E9CNM3
Locus tag SSYIS1_RS10005 Protein ID WP_006709290.1
Coordinates 1965436..1965702 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSYIS1_RS09985 1960775..1961860 + 1086 Protein_1917 glycine cleavage system aminomethyltransferase GcvT -
SSYIS1_RS09990 1961906..1962937 + 1032 WP_149590818.1 glycine cleavage system protein GcvH -
SSYIS1_RS09995 1963162..1963836 + 675 WP_006709288.1 hemolysin III family protein -
SSYIS1_RS10000 1964117..1965103 - 987 WP_006709289.1 tRNA-modifying protein YgfZ -
SSYIS1_RS10005 1965436..1965702 + 267 WP_006709290.1 FAD assembly factor SdhE Antitoxin
SSYIS1_RS10010 1965683..1966105 + 423 WP_006709291.1 protein YgfX Toxin
SSYIS1_RS10015 1966251..1966768 - 518 Protein_1923 flavodoxin FldB -
SSYIS1_RS10020 1967011..1967910 + 900 WP_006709292.1 site-specific tyrosine recombinase XerD -
SSYIS1_RS10025 1967923..1968639 + 717 WP_006709293.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
SSYIS1_RS10030 1968646..1970376 + 1731 WP_006709294.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16729.74 Da        Isoelectric Point: 9.8113

>T32659 WP_006709291.1 NZ_AP019531:1965683-1966105 [Serratia symbiotica]
VAQWRCDVCISRRTQLFSLLTHGVLVLLILISPWPAGYGPIWLVLLILVVFQGIRSQKRLAAVQGELRLLADWRINWHGR
EWRLVKKPWMPNYGILLTLHPMEGNKYQRLWLVLDNMEREEWRYLRQRLLYPPVSDDEET

Download         Length: 423 bp

>T32659 NZ_AP019531:1965683-1966105 [Serratia symbiotica]
GTGGCCCAGTGGCGATGTGATGTCTGCATTTCCAGGCGTACCCAATTATTCTCGTTGCTGACGCATGGCGTCCTGGTACT
GCTGATCCTGATTTCGCCTTGGCCAGCAGGCTACGGGCCGATCTGGCTAGTGCTGCTGATACTGGTGGTGTTTCAAGGTA
TCCGCAGCCAGAAACGCCTCGCCGCAGTGCAGGGCGAGTTGCGCCTGCTGGCGGACTGGCGCATCAACTGGCATGGCCGC
GAGTGGCGACTGGTGAAAAAACCTTGGATGCCGAATTACGGTATATTGCTGACACTGCACCCCATGGAGGGTAACAAGTA
CCAGCGGCTGTGGCTGGTTTTGGACAACATGGAGAGGGAAGAATGGCGCTATCTGCGCCAACGTCTGCTGTATCCACCAG
TGAGCGATGATGAAGAAACCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10401.91 Da        Isoelectric Point: 4.8052

>AT32659 WP_006709290.1 NZ_AP019531:1965436-1965702 [Serratia symbiotica]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDQLNDTDKALFIRLLECDDPDLFNWLMNHGAPEDSELQRMVALIQSRN
KARGPVAM

Download         Length: 267 bp

>AT32659 NZ_AP019531:1965436-1965702 [Serratia symbiotica]
ATGGATATTAACAACAAAGCACGCATCCATTGGGCCTGCCGCCGTGGCATGCGTGAGCTGGACATCTCCATCATGCCATT
CTTCGAATATGAGTATGACCAACTAAATGATACTGACAAGGCACTGTTTATCCGCCTGCTAGAGTGCGATGATCCCGATC
TGTTTAACTGGCTGATGAACCATGGCGCACCTGAGGACAGCGAACTGCAAAGAATGGTGGCCCTTATCCAGTCGCGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A455VHA9

Antitoxin

Source ID Structure
AlphaFold DB A0A068Z5F1

References