Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1497865..1498508 Replicon chromosome
Accession NZ_AP019531
Organism Serratia symbiotica strain IS

Toxin (Protein)


Gene name vagD Uniprot ID E9CJV7
Locus tag SSYIS1_RS07600 Protein ID WP_006707983.1
Coordinates 1497865..1498281 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID E9CJV8
Locus tag SSYIS1_RS07605 Protein ID WP_006707984.1
Coordinates 1498278..1498508 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSYIS1_RS07575 1492995..1493759 - 765 WP_149590964.1 fimbria/pilus periplasmic chaperone -
SSYIS1_RS07580 1494915..1495897 + 983 Protein_1458 IS481 family transposase -
SSYIS1_RS07585 1496367..1497113 - 747 WP_149590721.1 hypothetical protein -
SSYIS1_RS07590 1497234..1497575 - 342 WP_006707982.1 hypothetical protein -
SSYIS1_RS07600 1497865..1498281 - 417 WP_006707983.1 type II toxin-antitoxin system VapC family toxin Toxin
SSYIS1_RS07605 1498278..1498508 - 231 WP_006707984.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SSYIS1_RS07610 1498789..1499067 - 279 WP_006710054.1 hypothetical protein -
SSYIS1_RS07615 1499067..1499705 - 639 WP_006710053.1 AAA family ATPase -
SSYIS1_RS07620 1500217..1500861 + 645 WP_006707987.1 methylase -
SSYIS1_RS14735 1501532..1501954 + 423 WP_197737014.1 hypothetical protein -
SSYIS1_RS07630 1502061..1502477 + 417 WP_149590498.1 transposase -
SSYIS1_RS07635 1502474..1502824 + 351 WP_149590497.1 IS66 family insertion sequence element accessory protein TnpB -
SSYIS1_RS14580 1502849..1503013 + 165 WP_172624155.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - pilW / pilW 1481887..1558470 76583


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14949.24 Da        Isoelectric Point: 7.2152

>T32658 WP_006707983.1 NZ_AP019531:c1498281-1497865 [Serratia symbiotica]
VNKTYMLDTNICSFIMREQPEAVIKRLEQAVLRNHRIVVSAITYAEMCFGAIGKKASPRHAQLVDAFCARLDTVLAWDRA
AVDATTEIKAALATAGTPIGPNDTAIAGHAIAADAVLVTNNTREFARVPGLTLEDWVK

Download         Length: 417 bp

>T32658 NZ_AP019531:c1498281-1497865 [Serratia symbiotica]
GTGAACAAAACCTATATGCTGGACACCAACATTTGTTCTTTCATCATGCGTGAGCAGCCTGAAGCCGTGATCAAGCGTCT
TGAACAGGCGGTGCTGCGCAATCACCGCATCGTGGTGTCGGCGATCACCTATGCCGAAATGTGTTTCGGGGCGATCGGCA
AGAAGGCCTCGCCGCGCCACGCGCAGCTGGTCGACGCATTCTGCGCCCGACTGGATACCGTCCTAGCTTGGGACCGGGCA
GCGGTGGACGCCACTACGGAGATCAAGGCGGCACTTGCCACGGCCGGGACGCCGATCGGCCCGAACGATACGGCGATCGC
CGGGCATGCCATCGCCGCCGACGCCGTGCTGGTGACGAATAATACAAGAGAGTTTGCACGGGTGCCGGGTCTGACGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8809.06 Da        Isoelectric Point: 6.3202

>AT32658 WP_006707984.1 NZ_AP019531:c1498508-1498278 [Serratia symbiotica]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDRLILRPVRPTWGSFAQLEKANPDFMTKRMDVVSDEGRFDL

Download         Length: 231 bp

>AT32658 NZ_AP019531:c1498508-1498278 [Serratia symbiotica]
ATGCGAACCGTATCCATTTTTAAAAACGGCAATAACCGTGCTATCCGTCTTCCCCGCGATCTGGATTTTGATGGGGTGAG
CGAGCTGGAGATCGTCCGTGAAGGGGACAGACTCATCCTGCGCCCCGTCCGGCCGACCTGGGGCTCGTTCGCACAGTTGG
AAAAGGCCAACCCGGACTTTATGACGAAGCGTATGGACGTGGTTAGCGATGAAGGACGATTTGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A455VSQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A455VGK4

References