Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 72843..73455 Replicon chromosome
Accession NZ_AP019531
Organism Serratia symbiotica strain IS

Toxin (Protein)


Gene name hicA Uniprot ID E9CMQ7
Locus tag SSYIS1_RS00360 Protein ID WP_006709108.1
Coordinates 72843..73022 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID E9CMQ6
Locus tag SSYIS1_RS00365 Protein ID WP_006709107.1
Coordinates 73045..73455 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSYIS1_RS00345 68215..68982 - 768 WP_006709111.1 deoxyribose-phosphate aldolase -
SSYIS1_RS00350 69680..70462 - 783 WP_006709110.1 metal-dependent hydrolase -
SSYIS1_RS00355 71046..72635 - 1590 WP_149590504.1 peptide chain release factor 3 -
SSYIS1_RS00360 72843..73022 + 180 WP_006709108.1 type II toxin-antitoxin system HicA family toxin Toxin
SSYIS1_RS00365 73045..73455 + 411 WP_006709107.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SSYIS1_RS00370 73491..74084 - 594 WP_172624159.1 Ig-like domain-containing protein -
SSYIS1_RS00375 74586..75029 - 444 WP_006709106.1 ribosomal protein S18-alanine N-acetyltransferase -
SSYIS1_RS00380 74974..75411 - 438 WP_006709105.1 DNA polymerase III subunit psi -
SSYIS1_RS00385 75558..76604 + 1047 WP_006709104.1 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC -
SSYIS1_RS00395 76957..77768 + 812 Protein_78 IS110 family transposase -
SSYIS1_RS00400 78012..78306 - 295 Protein_79 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6760.93 Da        Isoelectric Point: 10.5502

>T32655 WP_006709108.1 NZ_AP019531:72843-73022 [Serratia symbiotica]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKDLVTVKHPQKDIPLPTLKSIKKQEGL

Download         Length: 180 bp

>T32655 NZ_AP019531:72843-73022 [Serratia symbiotica]
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTGAGAGTAAAAGGCAGTCATCACCAGTT
CAAGCACCCAACGAAAAAAGATCTGGTAACGGTAAAACATCCCCAAAAAGACATACCGCTACCAACACTAAAAAGTATCA
AGAAACAGGAGGGGCTTTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14742.72 Da        Isoelectric Point: 4.3299

>AT32655 WP_006709107.1 NZ_AP019531:73045-73455 [Serratia symbiotica]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESVREAIDAHIELLVEDGEAVPEATSVENWLADPDYAGVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRLAADKVIGRAKI

Download         Length: 411 bp

>AT32655 NZ_AP019531:73045-73455 [Serratia symbiotica]
ATGTTGTATCCCGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTGCCTGATATTCCAGGCTGCTTCTCTGG
CGGCGACAACTATCAGGATGCGATTGAGAGCGTACGTGAGGCTATCGACGCGCATATCGAATTACTGGTGGAAGATGGCG
AAGCGGTGCCGGAAGCCACCAGCGTTGAAAACTGGCTGGCCGATCCCGATTATGCTGGCGTAGTGTGGGCGCTGGTAGAC
GTGGACGTTACCCGGTTAATGGGGAAAGCGGAAAAAATCAACGTAACGCTTCCTTCTTTGCTGATTCGTCGTATCGACCA
GTTTGTCGCTGCACATCCTGAGTACGGTAGCCGTTCAGGCTTCCTGTCCCGTTTGGCGGCTGATAAAGTGATAGGTAGAG
CCAAAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A455VJS5

Antitoxin

Source ID Structure
AlphaFold DB A0A068RBW1

References