Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2492270..2492918 Replicon chromosome
Accession NZ_AP019516
Organism Psychrobacter sp. KH172YL61

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PKHYL_RS13300 Protein ID WP_240365371.1
Coordinates 2492270..2492551 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1D9D1W8
Locus tag PKHYL_RS13305 Protein ID WP_071003129.1
Coordinates 2492571..2492918 (+) Length 116 a.a.

Genomic Context

PKHYL_RS13275PKHYL_RS13280PKHYL_RS13295PKHYL_RS13300PKHYL_RS13305PKHYL_RS13310PKHYL_RS13315PKHYL_RS13320PKHYL_RS13325PKHYL_RS13340PKHYL_RS17750PKHYL_RS17755PKHYL_RS13330PKHYL_RS13335
Location: 2487589..2489072 (1484 bp)
Type: Others
Protein ID: Protein_2692
Location: 2489085..2490614 (1530 bp)
Type: Others
Protein ID: Protein_2693
Location: 2490969..2492210 (1242 bp)
Type: Others
Protein ID: WP_071003131.1
Location: 2492270..2492551 (282 bp)
Type: Toxin
Protein ID: WP_240365371.1
Location: 2492571..2492918 (348 bp)
Type: Antitoxin
Protein ID: WP_071003129.1
Location: 2493027..2493647 (621 bp)
Type: Others
Protein ID: WP_071003128.1
Location: 2493653..2494072 (420 bp)
Type: Others
Protein ID: WP_240365372.1
Location: 2494032..2494484 (453 bp)
Type: Others
Protein ID: WP_240365373.1
Location: 2494481..2495155 (675 bp)
Type: Others
Protein ID: WP_240365374.1
Location: 2496496..2497284 (789 bp)
Type: Others
Protein ID: WP_025645975.1
Location: 2497342..2497515 (174 bp)
Type: Others
Protein ID: WP_269778319.1
Location: 2497544..2497732 (189 bp)
Type: Others
Protein ID: WP_269778179.1
Location: 2495567..2496007 (441 bp)
Type: Others
Protein ID: WP_071003125.1
Location: 2496096..2496377 (282 bp)
Type: Others
Protein ID: WP_071003121.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PKHYL_RS13275 (PKHYL_32450)2487589..2489072+1484Protein_2692Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA-
PKHYL_RS13280 (PKHYL_32460)2489085..2490614+1530Protein_2693Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB-
PKHYL_RS13295 (PKHYL_32480)2490969..2492210+1242WP_071003131.1integrase arm-type DNA-binding domain-containing protein-
PKHYL_RS13300 (PKHYL_32490)2492270..2492551+282WP_240365371.1type II toxin-antitoxin system HicA family toxinToxin
PKHYL_RS13305 (PKHYL_32500)2492571..2492918+348WP_071003129.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
PKHYL_RS13310 (PKHYL_32510)2493027..2493647+621WP_071003128.1hypothetical protein-
PKHYL_RS13315 (PKHYL_32520)2493653..2494072+420WP_240365372.1transposase family protein-
PKHYL_RS13320 (PKHYL_32530)2494032..2494484+453WP_240365373.1transposase family protein-
PKHYL_RS13325 (PKHYL_32540)2494481..2495155+675WP_240365374.1hypothetical protein-
PKHYL_RS13330 (PKHYL_32550)2495567..2496007-441WP_071003125.1hypothetical protein-
PKHYL_RS13335 (PKHYL_32560)2496096..2496377-282WP_071003121.1DUF503 domain-containing protein-
PKHYL_RS13340 (PKHYL_32570)2496496..2497284+789WP_025645975.1threonine/serine exporter family protein-
PKHYL_RS177502497342..2497515+174WP_269778319.1hypothetical protein-
PKHYL_RS17755 (PKHYL_32580)2497544..2497732+189WP_269778179.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10276.79 Da        Isoelectric Point: 8.5815

>T32654 WP_240365371.1 NZ_AP019516:2492270-2492551 [Psychrobacter sp. KH172YL61]
MQRKHLKTLNIIFTKPISANIKWADIEALFIALGAEVNERAGSRIAVVLDGEVQVYHRPHPQPTTDKGAVASVRKWLDSL
GYSPIDEAKDTAP

Download         Length: 282 bp

>T32654 NZ_AP019516:2492270-2492551 [Psychrobacter sp. KH172YL61]
ATGCAGCGCAAGCACCTAAAAACACTTAATATCATCTTTACTAAGCCTATATCAGCAAATATAAAGTGGGCAGACATTGA
AGCCTTATTTATAGCATTAGGTGCAGAGGTCAACGAACGGGCAGGATCAAGAATAGCTGTAGTGTTAGATGGTGAGGTAC
AAGTTTATCACCGACCACACCCCCAACCGACAACAGATAAGGGCGCAGTCGCTAGCGTTCGTAAATGGCTAGATAGTTTA
GGGTATAGCCCTATTGATGAAGCCAAAGACACCGCCCCGTAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 12730.30 Da        Isoelectric Point: 4.3422

>AT32654 WP_071003129.1 NZ_AP019516:2492571-2492918 [Psychrobacter sp. KH172YL61]
MQNIMMINDHKALIQYDPELGLFRGEFVGLNGGADFYGDSIADLENEGKQSLQTFLDVCQEQGIEPYKSFSGKFVTRVPS
ELHEQVTTIATSHGMSLNQWVTNTLANAIKTEGMA

Download         Length: 348 bp

>AT32654 NZ_AP019516:2492571-2492918 [Psychrobacter sp. KH172YL61]
ATGCAAAACATTATGATGATTAATGACCATAAAGCACTTATTCAATATGACCCTGAACTAGGGTTATTCCGTGGAGAATT
TGTAGGGCTAAATGGTGGGGCAGACTTTTATGGTGACAGCATTGCCGATTTAGAAAATGAGGGTAAGCAGTCATTGCAAA
CCTTTTTGGACGTTTGCCAAGAACAAGGCATTGAGCCTTACAAATCCTTTTCAGGTAAGTTTGTAACCCGTGTGCCAAGT
GAGCTACACGAGCAAGTAACAACTATTGCCACCAGCCACGGTATGAGCCTTAACCAATGGGTCACTAATACACTTGCCAA
TGCCATCAAAACCGAAGGCATGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1D9D1W8

References