Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1548936..1549571 Replicon chromosome
Accession NZ_AP019400
Organism Cohnella abietis strain KCTC 43028

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KCTCHS21_RS06265 Protein ID WP_130605975.1
Coordinates 1549221..1549571 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KCTCHS21_RS06260 Protein ID WP_130605973.1
Coordinates 1548936..1549217 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCTCHS21_RS06245 1545142..1545873 - 732 WP_157993966.1 methyltransferase domain-containing protein -
KCTCHS21_RS06250 1546208..1547344 + 1137 WP_130605969.1 outer membrane lipoprotein carrier protein LolA -
KCTCHS21_RS06255 1547560..1548747 + 1188 WP_130605971.1 alanine racemase -
KCTCHS21_RS06260 1548936..1549217 + 282 WP_130605973.1 ribbon-helix-helix protein, CopG family Antitoxin
KCTCHS21_RS06265 1549221..1549571 + 351 WP_130605975.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KCTCHS21_RS06270 1549658..1550890 + 1233 WP_130605977.1 aminopeptidase -
KCTCHS21_RS06275 1551055..1553235 + 2181 WP_130605979.1 RNA-binding transcriptional accessory protein -
KCTCHS21_RS06280 1553368..1553835 + 468 WP_130605981.1 Rrf2 family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12932.94 Da        Isoelectric Point: 5.6439

>T32646 WP_130605975.1 NZ_AP019400:1549221-1549571 [Cohnella abietis]
MIVKRGDVFYADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIEAKNHGMERDSVILLEQI
RTIDKQRLTDKITHLDDETMRKVDEALQISVGLIDF

Download         Length: 351 bp

>T32646 NZ_AP019400:1549221-1549571 [Cohnella abietis]
TTGATTGTGAAGCGCGGGGATGTTTTCTACGCCGATTTGTCGCCGGTCGTTGGTTCGGAGCAGGGTGGTGTTCGTCCTGT
TCTTGTTATCCAGAATGATATTGGCAACCGTTTTAGCCCAACAGTTATTATTGCGGCTATAACGGCTCAGATTCAGAAAG
CGAAGCTGCCCACACACGTCGAAATCGAAGCAAAGAATCATGGCATGGAGCGCGACTCGGTTATCCTGCTTGAGCAAATC
CGCACAATCGATAAGCAACGATTAACGGACAAAATCACGCATCTGGACGATGAGACCATGCGCAAGGTGGATGAAGCTTT
GCAGATTAGCGTAGGATTAATTGATTTCTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10743.45 Da        Isoelectric Point: 9.6914

>AT32646 WP_130605973.1 NZ_AP019400:1548936-1549217 [Cohnella abietis]
VANLHNTKRIMISLPDHLLREVDFVVAKENTNRSEIIRQAMKHYLVDRKKRLIRDAMQRGYLEMAKINLNMASEAFHAEE
DADNILGRLVSGV

Download         Length: 282 bp

>AT32646 NZ_AP019400:1548936-1549217 [Cohnella abietis]
GTGGCCAATTTACACAATACGAAACGCATTATGATCAGTCTTCCGGATCATTTGCTGCGTGAAGTCGACTTCGTAGTCGC
CAAGGAAAATACCAACCGCAGCGAGATAATCCGCCAGGCTATGAAGCATTACTTAGTTGATCGCAAGAAGCGGTTAATTC
GTGATGCGATGCAACGTGGCTATTTGGAAATGGCCAAGATCAATCTGAATATGGCATCTGAAGCTTTTCACGCCGAAGAA
GATGCCGACAATATACTCGGACGCCTCGTAAGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References